Specific decrease of anti-pseudomonal IgA after anti-pseudomonal therapy in cystic fibrosis |
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Authors: | K de Boeck E Eggermont M Smet P van Reempts H P van Bever W J Stevens |
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Institution: | (1) Department of Paediatrics, University Hospital of Leuven, Herestraat 49, B-3000 Leuven, Belgium;(2) Department of Immunology, University Hospital of Antwerp, Belgium |
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Abstract: | In patients with cystic fibrosis (CF) and chronic colonisation withPseudomonas aeruginosa, specific anti-pseudomonal IgG and IgA, as well as serum immunoreactive protein C, WBC and differential count, ESR, pulmonary function and chest radiograph score were determined before and after a 2 week intravenous course of anti-pseudomonal antibiotics in 32 cases of acute exacerbation of pulmonary infection. Specific anti-pseudomonal IgA but not specific anti-pseudomonal IgG decreased significantly after treatment. Log of anti-pseudomonal IgA but not log anti-pseudomonal IgG correlated well with disease severity as assessed by the Brasfield chest radiograph score (r 0.57), forced expiratory volume in 1 s (r 0.6) as well as C-reactive protein (r 0.62). |
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Keywords: | Cystic fibrosis Pseudomonas aeruginosa IgA antibodies IgG antibodies |
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