International validation of a behavioral scale in Parkinson's disease without dementia |
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| Authors: | Isabelle Rieu Pablo Martinez‐Martin Bruno Pereira Ingrid De Chazeron Leo Verhagen Metman Marjan Jahanshahi Claire Ardouin Isabelle Chéreau Christine Brefel‐Courbon Fabienne Ory‐Magne Helene Klinger Fleur Peyrol Michael Schupbach Kathy Dujardin François Tison Jean Luc Houeto Paul Krack Franck Durif |
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| Affiliation: | 1. CHU Clermont‐Ferrand, Neurology Department;2. CHU Gabriel Montpied, Clermont‐Ferrand, France;3. Université Clermont 1, UFR Medecine, EA7280, Clermont‐Ferrand, France;4. Alzheimer Centre Reina Sofia Foundation and CIBERNED, Carlos III Institute of Health, Madrid, Spain;5. CHU Clermont‐Ferrand, DRCI, Biostatistics Unit, Clermont‐Ferrand F, France;6. CHU Clermont‐Ferrand, Department of Psychiatry B, CHU Gabriel Montpied, Clermont‐Ferrand F‐63000, France;7. Rush University, Department of neurological Sciences, Section of Movement Disorders, Chicago, Illinois, USA;8. Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK;9. Movement Disorder Unit, Department of Psychiatry and Neurology, CHU de Grenoble, Joseph Fourier University and INSERM, Unité 836, Grenoble Institut des Neurosciences, Grenoble, France;10. University, Hospital Toulouse, Neurology Department, CHU Purpan, Toulouse, France;11. Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Neurologie C, Lyon, France;12. Santé publique, CHU de Clermont‐Ferrand, 63058 Clermont‐Ferrand, France;13. UPMC Paris 6, Inserm CRICM UMR‐S975, Neurology Department, H?pital de la Salpêtrière, Assistance Publique H?pitaux de Paris, France;14. Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France;15. University of Bordeaux, Institut des Maladies Neurodégénératives, CNRS UMR 5293 et CHU de Bordeaux, France;16. Neurology Department, CIC INSERM‐0802CHU de Poitiers 86021 Poitiers cedex;17. INSERM U 1084, Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers |
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| Abstract: | The “Ardouin Scale of Behavior in Parkinson's Disease” is a new instrument specifically designed for assessing mood and behavior with a view to quantifying changes related to Parkinson's disease, to dopaminergic medication, and to non‐motor fluctuations. This study was aimed at analyzing the psychometric attributes of this scale in patients with Parkinson's disease without dementia. In addition to this scale, the following measures were applied: the Unified Parkinson's Disease Rating Scale, the Montgomery and Asberg Depression Rating Scale, the Lille Apathy Rating Scale, the Bech and Rafaelsen Mania Scale, the Positive and Negative Syndrome Scale, the MacElroy Criteria, the Patrick Carnes criteria, the Hospital Anxiety and Depression Scale, and the Mini‐International Neuropsychiatric Interview. Patients (n = 260) were recruited at 13 centers across four countries (France, Spain, United Kingdom, and United States). Cronbach's alpha coefficient for domains ranged from 0.69 to 0.78. Regarding test–retest reliability, the kappa coefficient for items was higher than 0.4. For inter‐rater reliability, the kappa values were 0.29 to 0.81. Furthermore, most of the items from the Ardouin Scale of Behavior in Parkinson's Disease correlated with the corresponding items of the other scales, depressed mood with the Montgomery and Asberg Depression Rating Scale (ρ = 0.82); anxiety with the Hospital Anxiety and Depression Scale—anxiety (ρ = 0.56); apathy with the Lille Apathy Rating Scale (ρ = 0.60). The Ardouin Scale of Behavior in Parkinson's disease is an acceptable, reproducible, valid, and precise assessment for evaluating changes in behavior in patients with Parkinson's disease without dementia. © 2015 International Parkinson and Movement Disorder Society |
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| Keywords: | clinical trials observational study Parkinson's disease neuropsychological and behavioral assessments psychiatric disorders |
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