| 粉防己碱-胶原复合膜对大鼠单纯切割伤和放射切割复合伤创面愈合的作用 |
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| 引用本文： | 孟德胜,胡友梅,程天民. 粉防己碱-胶原复合膜对大鼠单纯切割伤和放射切割复合伤创面愈合的作用[J]. 第三军医大学学报, 1999, 21(2): 78-80 |
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| 作者姓名： | 孟德胜 胡友梅 程天民 |
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| 作者单位： | 1. 第三军医大学基础医学部药理学教研室,重庆,400038
2. 第三军医大学预防医学系防原教研室、全军复合伤研究所,重庆,400038 |
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| 摘 要： | 目的:观察粉防己碱-胶原复合膜对大鼠单纯切割伤和放射切割复合伤创面愈合的作用.方法:大鼠双侧同体对照,用药后不同时间测定创面愈合率和肉芽组织中蛋白、DNA、羟脯氢酸的含量.结果:含粉防己碱0.25%～0.50%的外用药膜可有效促进单纯切割伤创面愈合,创面缩小较快,肉芽组织中蛋白、DNA、羟脯氨酸的含量较对照组明显增多.而各剂量组对放射切割复合伤均无效.结论:粉防己碱-胶原复合膜对单纯切割伤具有促进愈合的作用,而对放射切割复合伤无效.
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| 关 键 词： | 粉防己碱 胶原 膜剂 切割伤 放射切割复合伤 大鼠 |
Effects of pelliculea of tetrandrine et collagen compositus on wound healing after excision and combined radiation-excision injury in rats |
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| Meng Desheng,Hu Youmei,Cheng Tianmin. Effects of pelliculea of tetrandrine et collagen compositus on wound healing after excision and combined radiation-excision injury in rats[J]. Acta Academiae Medicinae Militaris Tertiae, 1999, 21(2): 78-80 |
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| Authors: | Meng Desheng Hu Youmei Cheng Tianmin |
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| Abstract: | ObjectiveTo investigate the effects of the pelliculea of tetrandrine (Tet) et collagen composituson wound healing after excision and combined radiation-excision injury in rats. MethodsThe skin on both sides on the back of rats was excised. The wound on one side was treatedwith Tet and that on the other was not. At different time phases after excision, the rateof wound healing and the contents of protein, DNA and hydroxyproline of the granulationtissue were determined. Results When the dose of Tet ranged from 0.25%to 0.5%, the wound healing of the excision was promoted and the contents of protein, DNAand hydroxyproline of the granulation tissue were much higher than those in the control.However, these results were not seen in the wound caused by excision and radiation incombination. Conclusion The pelliculea of Tet et collagen compositus can promote thewound healing of excision injury but can not that of combined radiation-excision injury. |
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