| 多囊卵巢综合征患者子宫内膜mPGES-1和COX-2表达的研究 |
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| 引用本文： | 刘聪慧,周跃闻,陈昭,侯灵彤.多囊卵巢综合征患者子宫内膜mPGES-1和COX-2表达的研究[J].现代妇产科进展,2011,20(7):559-562. |
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| 作者姓名： | 刘聪慧 周跃闻 陈昭 侯灵彤 |
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| 作者单位： | 1. 河北联合大学附属医院妇产科,唐山,063000
2. 唐山市协和医院妇产科,唐山,063000 |
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| 基金项目： | 唐山市科技攻关项目基金资助(No:05134614e) |
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| 摘 要： | 目的:探讨多囊卵巢综合征(PCOS)患者膜结合型前列腺素合酶-1(mPGES-1)和环氧合酶-2(COX-2)在子宫内膜组织的表达及临床意义。方法:选择2005年6月至2007年6月华北煤炭医学院生殖内分泌门诊诊断为PCOS的患者21例为PCOS组,卵巢功能正常的不孕患者20例为对照组。PCOS组采用二甲双胍/达英-35联合治疗。病例均测体重、身高、性激素六项及75g葡萄糖耐量试验(OGTT)和胰岛素释放试验(IRT)。并于月经干净3～5天(闭经患者确认为卵泡期)取子宫内膜组织,采用免疫组织化学技术检测PCOS组治疗前后及对照组中mPGES-1和COX-2的表达。结果:PCOS组患者BMI、HOMA-IR、空腹胰岛素(I0)、75g葡萄糖负荷后2h胰岛素(I120)及T均明显高于对照组患者(P均<0.05);治疗前PCOS组mPGES-1和COX-2在子宫内膜的表达显著高于对照组(P<0.01),治疗后两因子的表达与治疗前比较明显下降(P<0.01)。结论:PCOS患者子宫内膜可能处于一种慢性炎症状态,子宫内膜mPGES-1和COX-2过度表达可能是导致患者子宫内膜异常增生和不孕的原因之一,二甲双胍/达英-35联合应用可逆转该炎症状态,可能有利于孕卵着床和预防子宫内膜癌发生。
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| 关 键 词： | 多囊卵巢综合征 子宫内膜 环氧合酶-2 膜结合型前列腺素合酶-1 二甲双胍 达英-35 |
Study of microsomal prostaglandin E_2 synthase-1 and cyclooxygenase-2 expression in endometrium of patients with polycystic ovary syndrome |
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| Liu Conghui,Zhou Yuewen,Chen Zhao,et al..Study of microsomal prostaglandin E_2 synthase-1 and cyclooxygenase-2 expression in endometrium of patients with polycystic ovary syndrome[J].Current Advances In Obstetrics and Gynecology,2011,20(7):559-562. |
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| Authors: | Liu Conghui Zhou Yuewen Chen Zhao |
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| Institution: | Liu Conghui1,Zhou Yuewen2,Chen Zhao1,et al.1.Department of Gynecology and Obstetrics,the Affiliated Hospital of Hebei United University,Tangshan 063000,2.Department of Gynecology and Obstetrics,Tangshan Xiehe Hospital |
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| Abstract: | Objective:To study the expression and role of microsomal prostaglandin E2 synthase-1(mPGES-1) and cyclooxygenase-2(COX-2) in endometrium of patients with polycystic ovary syndrome(PCOS).Methods:16 PCOS cases(PCOS group) and 20 infertile women with normal ovary function(control group) were selected,and PCOS cases were treated with Metformin/Diane-35.Body mass index(BMI),sex hormone concentration,75g oral glucose tolerance tests(OGTT) and insulin release tests(IRT) were tested in all cases,and Homeostatic mod... |
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| Keywords: | Polycystic ovary syndrome Endometrium Cyclooxygenase-2 Microsomal prostaglandin E2 synthase-1 Metformin Diane-35 |
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