不同年龄及性别健康成人血浆同型半胱氨酸的水平研究

目的: 分析不同性别及年龄健康成人的血浆同型半胱氨酸(Hcy)水平,明确健康人群Hcy的标准,为高Hcy血症的防治提供指导和依据。方法: 剔除高血压、脑卒中、冠心病等常见致血Hcy升高因素的健康体检人群,共738人,按不同年龄分为青(≤35岁)、中(≥36,<60岁)、老(≥60岁)3组,并按性别分为男女亚组,以循环酶法分别测定其血浆Hcy水平,进行比较。结果: 各年龄组男性均高于女性(P<0.01);同时男女各组Hcy均随年龄增加而升高,青、中、老组比均有显著差异(P<0.01);男性均数为13.26 μmol/L,女性为9.68 μmol/L,差异显著(P<0.01); 多数男性(73.21%)血Hcy水平在10.01-15.00 μmol/L间,多数女性(84.06%)小于10.00 μmol/L。 结论: (1) 健康成人血浆Hcy水平存在性别和年龄的差异,男性高于女性,并随年龄增加而逐渐升高。(2) 正常健康成人血浆Hcy水平高限的确定,应考虑性别及年龄因素。

Plasma homocysteine levels in health adult subjects with different age and sex

AIM: To establish a guidance of homocysteine (Hcy) level in healthy adults for prevention and treatment of high plasma Hcy by determining the Hcy concentration in healthy subjects with different sex and age.METHODS: After the common factors of the high plasma Hcy such as hypertension, stroke, coronary heart disease and so on were eliminated, 738 subjects were selected and divided into 3 groups: the young (≤35), the middle-aged (≥36, <60) and the old age (≥60). According to the ages, the male and female subgroups were also divided. The plasma Hcy levels were determined by enzymatic cycling assay.RESULTS: The Hcy levels in the males were higher than those in the females in each group (P<0.01) and the levels of Hcy increased with age in both groups. The concentrations of Hcy between the groups of young, the middle-aged and the old age were obviously different (P<0.01). The mean value in male was 13.26 μmol/L vs that in female of 9.68 μmol/L (P<0.01). In most males (73.21%), the Hcy levels were 10.01-15.00 μmol/L. The Hcy levels in most females (84.06%) were < 10.00 μmol/L. CONCLUSION: The plasma Hcy levels are obviously different in healthy adults according to the sex and age: the Hcy levels in the males are higher than those in the females, and increases gradually with age. To determine the maximum level of plasma Hcy in healthy adults, the factors of sex and age should be considered.