Predicting Factors of Severe COVID-19 in Patients With Asthma: A Korean National Cohort Study |
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| Authors: | Hyun Lee Hayoung Choi Sun-Kyung Lee Tai Sun Park Dong Won Park Ji-Yong Moon Tae-Hyung Kim Jang Won Sohn Ho Joo Yoon Sang-Heon Kim |
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| Affiliation: | 1.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.;2.Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.;3.Department of Mathematics, College of Natural Sciences, Hanyang University, Seoul, Korea. |
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| Abstract: | As there are limited data on the disease course of and factors predicting severe coronavirus disease 19 (COVID-19) in patients with asthma, this study aims to perform a detailed analysis of the clinical course of asthmatic patients with COVID-19 and evaluate factors related to severe infection. Of the 5,628 patients confirmed with COVID-19, 128 (2.3%) had asthma. Among the 128 asthmatic patients, 32 (25%) had severe COVID-19 and 96 (75%) had non-severe COVID-19. Among asthmatic patients, those with severe COVID-19 were significantly older and had more dyspnea and fever, more comorbidities, and lower lymphocyte and platelet counts than those with non-severe COVID-19. In multivariable logistic regression analysis, chronic obstructive pulmonary disease (adjusted odds ratio [aOR], 6.49; 95% confidence interval [CI], 1.18–41.81), low lymphocyte proportion (aOR, 0.91; 95% CI, 0.86–0.97), and low platelet count (aOR, 0.99; 95% CI, 0.98–0.99) were independently associated with severe COVID-19. |
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| Keywords: | Asthma COVID-19 chronic obstructive pulmonary disease |
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