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| 消炎利胆片防治大鼠急性肝损伤的实验研究 | |
| 引用本文： | 叶木荣,长尾由纪子,李楚源,王德勤,陈建南,赖小平. 消炎利胆片防治大鼠急性肝损伤的实验研究[J]. 中成药, 2006, 28(11): 1616-1619 |
| 作者姓名： | 叶木荣 长尾由纪子 李楚源 王德勤 陈建南 赖小平 |
| 作者单位： | 1. 广州中医药大学,中药学院 2. 广州中医药大学新药开发研究中心,广东,广州,510405 3. 广州白云山和记黄埔中药有限公司,广东,广州,510000 |
| 摘 要： | 目的:研究消炎利胆片(穿心莲、溪黄草、苦木等)对大鼠急性肝损伤的保护作用。方法:分别采用四氯化碳(CC l4)和D-半乳糖胺(D-galactosam ine,D-Gal)腹腔注射造成大鼠急性肝损伤,测定血清生化指标,并测体重和肝脏重、脾重和胸腺重,求脏器系数。同时切取肝脏检测肝糖原,并取肝组织作病理观察。结果:消炎利胆片可显著降低CC l4和D-Gal诱导的急性化学性肝损伤大鼠血清ALT、AST、ALP水平及TBA和T-B il含量。病理检查结果也显示有明显的保肝作用。结论:消炎利胆片对CC l4和D-Gal所致大鼠急性肝损伤有保护作用。 |
| 关 键 词： | 消炎利胆片 四氯化碳 D-半乳糖胺 急性肝损伤 大鼠 |
| 文章编号： | 1001-1528（2006）10-1616-04 |
| 收稿时间： | 2005-10-22 |
| 修稿时间： | 2005-10-22 |
Protective effect of Xiaoyan Lidan Tablet on acute hepatic injury in rats |
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| YE Mu-rong,Nagao Yu-ki-ko,LI Chu-yuan,WANG De-qin,CHEN Jian-nan,LAI Xiao-ping. Protective effect of Xiaoyan Lidan Tablet on acute hepatic injury in rats[J]. Chinese Traditional Patent Medicine, 2006, 28(11): 1616-1619 | |
| Authors: | YE Mu-rong Nagao Yu-ki-ko LI Chu-yuan WANG De-qin CHEN Jian-nan LAI Xiao-ping |
| Affiliation: | 1. College of Chinese Drug,2. New Drug Research and Development Center,Guangzhou Univenity of Traditional Chinese Medici,Guangzhou 510405 China ;3. Hutchson Whampoa Guangzhou Baiyunshan Chinese Medicine Co. , Ltd Guangzhou 510000, China |
| Abstract: | AIM: To study the protective effects of Xiaoyan Lidan Tablet(Herba Andrographis,Herba Rabdosiae serrae,Radix Sophorae Flavescentis,etc) on acute hepatic injury in rats. METHODS: Acute hepatic injury was induced by intraperitoneal(ip) injection of carbon tetrachloride and D-galactosamine,respectively.The levels of ALT,AST,ALP,TBA,total bilirubin(T-Bil),total protein (TP) and albumin(ALB) in serum were analyzed.The body weight,liver weight,spleen weight and thymus weight of each rat were measured.The hepatic glycogen content was analyzed individually.Liver tissue pathology was observed. RESULTS: Xiayan Lidan Tablet can decrease ALT,AST,ALP,TBA and T-Bil in serum,reduce necrosis in pathological observation. CONCLUSION: Xiaoyan Lidan Tablet gives the protective effects to acute hepatic injury induced by CCl_4 and D-Gal in rats. |
| Keywords: | Xiaoyan Lidan Tablet carbon tetrachloride D-galactosamine acute hepatic injury rats |
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