C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC) |
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| Authors: | Bezemer Irene D Rinaldi Sabina Dossus Laure Gils Carla H van Peeters Petra H M Noord Paulus A H van Bueno-de-Mesquita H Bas Johnsen Soren Paaske Overvad Kim Olsen Anja Tjønneland Anne Boeing Heiner Lahmann Petra H Linseisen Jakob Nagel Gabriele Allen Naomi Roddam Andrew Bingham Sheila Khaw Kay-Tee Kesse Emmanuelle Téhard Bertrand Clavel-Chapelon Françoise Agudo Antonio Ardanaz Eva Quiros J R Amiano Pilar Martínez-Garcia C Tormo M J Pala Valeria Panico Salvatore Vineis Paolo Palli Domenico Tumino Rosario Trichopoulou Antonia Baibas N Zilis D Hémon Bertrand Norat Teresa Riboli Elio Kaaks Rudolf |
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| Institution: | (1) International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France;(2) Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands;(3) Department of Epidemiology, National Institute of Public Health and Environment, Bilthoven, The Netherlands;(4) Institute of Epidemiology & Social Medicine, University of Aarhus, Aarhus, Denmark;(5) Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;(6) Department of Epidemiology, Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, Germany;(7) Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany;(8) Epidemiology Unit, Cancer Research UK, Oxford, UK;(9) MRC Dunn Human Nutrition Unit, Welcome Trust/MRC Building, Cambridge, UK;(10) Clinical Gerontology Unit, Addenbrooke’s Hospital, Cambridge, UK;(11) Institut Gustave Roussy, INSERM, Villejuif, France;(12) Department of Epidemiology, Catalan Institute of Oncology (ICO), Barcelona, Spain;(13) Public Health Institute of Navarra, Spain;(14) Health Council of Asturias, Spain;(15) Health Department of Basque Country, Spain;(16) Andalusian School of Public Health, Granada, Spain;(17) Epidemiology Department, Murcia Health Council, Murcia, Spain;(18) National Cancer Institute, Milan, Italy;(19) Department for Clinical and Experimental Medicine, Federico II University Naples, Naples, Italy;(20) University of Torino and Imperial College London, London, UK;(21) Molecular and Nutritional Epidemiology Unit CSPO-Scientific Institute of Tuscany, Florence, Italy;(22) Cancer Registry of Sicily, Ragusa, Italy;(23) University of Athens Medical School, Athens, Greece |
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| Abstract: | Objectives: The risk of some cancers is positively associated with body weight, which may influence circulating levels of sex-steroid hormones, insulin and IGF-I. Interrelationships between these hormones and the associations with adiposity were evaluated in healthy women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC).Methods: A cross-sectional analysis was performed on anthropometric and hormonal data from 743 pre- and 1217 postmenopausal women. Body mass index (BMI) and waist circumference were used as indicators of adiposity. C-peptide, Insulin Growth Factor (IGF)-I, Insulin Growth Factor binding protein (IGFBP)-3, androgens, estrogens and sex hormone binding globulin (SHBG) were measured by immunoassays; free sex steroid concentrations were calculated.Results: BMI and waist circumference were positively correlated with estrogens in postmenopausal women and with C-peptide, free testosterone and inversely with SHBG in all women. C-peptide and IGF-I were inversely correlated with SHBG, and positively with free sex steroids in postmenopausal women. IGF-I was positively associated with postmenopausal estrogens and androgen concentrations in all women.Conclusions: Sex-steroid concentrations appear to be regulated along several axes. Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids. Independent of adiposity and insulin, IGF-I was associated with decreased SHBG levels, and increased concentrations of androgens and postmenopausal estrogens. |
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| Keywords: | anthropometry sex-steroid hormones insulin IGF-I |
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