Selection during cefepime treatment of a new cephalosporinase variant with extended-spectrum resistance to cefepime in an Enterobacter aerogenes clinical isolate |
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| Authors: | Barnaud G Benzerara Y Gravisse J Raskine L Sanson-Le Pors M J Labia R Arlet G |
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| Affiliation: | Service de Bactériologie, Hôpital Tenon AP-HP,1 Service de Bactériologie-Virologie, Hôpital Lariboisière AP-HP, Paris,2 CNRS-UBO-MNHN, Unité FRE 2125, Quimper, France3 |
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| Abstract: | Enterobacter aerogenes resistant to cefepime (MIC, 32 microg/ml) was isolated from a patient treated with cefepime for an infection caused by a strain of E. aerogenes overproducing its AmpC beta-lactamase (MIC of cefepime, 0.5 microg/ml). The AmpC beta-lactamase of the resistant strain had an L-293-P amino acid substitution and a high k(cat)/K(m) ratio for cefepime. Both of these modifications were necessary for resistance to cefepime. |
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