Zaltoprofen inhibits concanavalin A-induced decrease of body weight in mice |
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Authors: | Okamoto T Kawasaki T Masuda Y |
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Affiliation: | Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341-0005, Japan. |
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Abstract: | Treatment of mice with concanavalin A (Con A) (12.5 mg/kg, i.v.) decreased the body weight at 24 h. This Con A-induced body weight decrease was accompanied by reduction in food and water intake. Zaltoprofen is a non-steroidal anti-inflammatory drug. The administration of Zaltoprofen (10 mg/kg) at 8 h after Con A treatment was found to inhibit the Con A-induced reduction in body weight. The food intake in mice treated with Con A plus Zaltoprofen (10 mg/kg) was four times greater than that in mice treated with only Con A. The present results showed inhibition of the Con A-induced body weight loss by Zaltoprofen and suggested its possible effectiveness for the treatment of "sickness behavior". |
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