Apomorphine-like effect of an aminotetralin on the linguomandibular reflex of the cat. |
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| Authors: | M Ilhan D E Nichols J P Long J G Cannon |
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| Affiliation: | 1. Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A.;2. Division of Medicinal Chemistry and Natural Products, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, U.S.A. |
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| Abstract: | Low doses of 5,6-dihydroxy-2-dimethylaminotetralin (M-7) produced inhibition of the linguomandibular reflex in the cat. This inhibition was similar to that produced by apomorphine and was blocked by haloperidol, bulbocapnine or chlorpromazine. M-7 also had a brief but marked hypertensive effect. Gradual bradycardia also developed. These results indicate that M-7 inhibits the linguomandibular reflex by interaction at dopamine receptors, or 'apomorphine' receptors. |
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| Keywords: | Apomorphine Aminotetralin Dopamine receptors Linguomandibular reflex |
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