Effect of peptide AS-48 on Enterococcus faecalis subsp. liquefaciens S-47. |
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Authors: | A Galvez E Valdivia M Martinez M Maqueda |
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Affiliation: | Departamento de Microbiologia, Facultad de Ciencias, Universidad de Granada, Spain. |
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Abstract: | The enterococcal peptide AS-48 exerts a concentration-dependent bactericidal effect on Enterococcus faecalis subsp. liquefaciens S-47; cell rescue by cardiolipin and trypsin can be effected only in the first few minutes after antibiotic addition. Gramicidin-exposed cells are protected from killing by AS-48. Long-term and pulse incorporation of radiolabeled substrates into trichloroacetic acid-precipitable material, O2 consumption, and the ability to maintain intracellular potassium levels are impaired shortly after addition of AS-48. |
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