| 红藻氨酸诱导癫痫发作鼠脑HSP70表达与组织细胞凋亡关系的研究 |
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| 引用本文： | 崔荣太,李晓华,强琳,黄远桂. 红藻氨酸诱导癫痫发作鼠脑HSP70表达与组织细胞凋亡关系的研究[J]. 脑与神经疾病杂志, 2001, 9(4): 202-203 |
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| 作者姓名： | 崔荣太 李晓华 强琳 黄远桂 |
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| 作者单位： | 1. 青岛解放军401医院神经内科,
2. 青岛儿童医院儿保科 |
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| 摘 要： | 目的 :探讨红藻氨酸诱导癫痫发作鼠脑 HSP70表达与组织细胞凋亡的关系。方法 :用流式细胞术及免疫印迹法分别检测红藻氨酸诱导癫痫发作鼠脑海马结构组织细胞不同时间的凋亡率及 HSP70表达量。结果 :红藻氨酸注射后 3小时 ,HSP70表达量即开始增高 ,6小时凋亡率始升高 ,至 4 8小时 ,二者同时达到高峰 (P<0 .0 1) ,此后开始下降。结论 :HSP70是调节红藻氨酸诱导癫痫发作鼠脑细胞凋亡的重要分子之一
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| 关 键 词： | 癫痫发作 热休克蛋白70 凋亡 |
| 修稿时间： | 2001-03-27 |
Research on the releationship between neuronal apoptosis and expression of HSP70 in rat brain during kainic acid-induced seizures |
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| CUI Rongtai,LI Xiaohua,QIANG Lin,et al.. Research on the releationship between neuronal apoptosis and expression of HSP70 in rat brain during kainic acid-induced seizures[J]. Journal of Brain and Nervous Diseases, 2001, 9(4): 202-203 |
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| Authors: | CUI Rongtai LI Xiaohua QIANG Lin et al. |
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| Affiliation: | CUI Rongtai,LI Xiaohua,QIANG Lin,et al. Department of Neurology,PLA 401 Hospital,Qingdao 266071 |
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| Abstract: | Objective: To study the reeationship between neuronal apoptosis and expression of HSP70 in rat brain during kainic acid-induced seizures. Methods: To measure the rate of neuronal apoptosis and expression of HSP70 by flow cytometry (FCM) and westem blots respectiovely.Results: The expression of HSP70 was markedly higher than those of the controls at 3h and apoptotic rate was at 6h, both reached the peak at 48h.Conclusion: HSP70 is one of the important molecules which regulate apoptosis during KA-induced seizures. |
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| Keywords: | seizure HSP70 apoptosis |
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