Long-term prognosis of primary retroperitoneal soft tissue sarcoma. |
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Authors: | Th van Dalen J M Plooij F van Coevorden A N van Geel H J Hoekstra Ch Albus-Lutter P J Slootweg A Hennipman |
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Affiliation: | Members of Dutch Soft Tissue Sarcoma Group, PO Box 19079, 3501 DB Utrecht, The Netherlands. thijsvandalen@hccnet.nl |
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Abstract: | AIMS: To evaluate the result of treatment and long-term outcome of a population-based cohort of patients with retroperitoneal soft tissue sarcoma (RSTS). METHODS: Between 1 January 1989 and 1 January 1994, 143 patients diagnosed as having primary RSTS were selected from a national pathology database (PALGA) in the Netherlands. In this population-based group of patients, the result of surgery, overall survival (OS) and disease-free survival (DFS) were analysed as well as factors affecting OS and DFS. Median follow-up was 10.2 years. RESULTS: Operative treatment resulted in a complete tumour resection in 55% of the patients (n=78), low- and intermediate-grade tumours were more often completely resected than high-grade tumours (P=0.016). Five- and 10-year cumulative OS was 39% and 21%, respectively, while DFS was 22% and 17%, respectively. In a multivariate analysis low malignancy grade (P=0.017) and a complete tumour resection (P<0.001) were associated with better OS. CONCLUSIONS: Complete tumour resection and low malignancy grade were independent favourable prognosticators. However, these factors were related too, since surgical success was influenced by malignancy grade. |
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Keywords: | Soft tissue sarcoma Retroperitoneum Tumour biology Prognostic factors |
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