Susceptibility of Candida albicans to flucytosine when tested in different formulations of yeast nitrogen base broth |
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| Authors: | J N Galgiani C A Yturralde K O Dugger |
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| Institution: | 1. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China;2. School of Chemical Science and Technology, Yunnan University, Kunming 650091, China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China |
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| Abstract: | The influence of various formulations of yeast nitrogen base broth and temperature on the flucytosine sensitivity of Candida albicans was examined. Each of 15 isolates was tested concurrently in yeast nitrogen base from two different suppliers, with or without supplemental dextrose and L-asparagine, and with incubation at either 30 degrees C or 37 degrees C. Observed differences were related to media source, media supplementation, and temperature of incubation. For all three variables, higher endpoint results were associated with greater rates of yeast growth as reflected by turbidity after 24 hr of incubation. Despite these differences, their magnitudes were sufficiently small so that variations in yeast nitrogen base formulation appear not to be an important source of imprecision in susceptibility testing of yeasts. |
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