基于颜色模型的乳腺癌舌象客观化研究

目的 通过收集乳腺癌不同中医证型、不同临床分期、不同分子分型舌象图像数据信息,观察其与舌象特征的相关性,为乳腺癌的舌象客观化研究提供参考数据.方法 选取2019年6月—2021年1月期间于北京中医药大学东直门医院血液肿瘤科就诊的乳腺癌患者,使用TFDA-1型数字舌诊仪采集乳腺癌患者舌象图片,以Matlab为图像处理系统...

Objective Study on Tongue Image of Breast Cancer Based on Color Model

Objective To study the correlation between different TCM syndromes,different clinical stages and different molecular types of breast cancer by collecting tongue image data information,so as to provide reference data for the objective study on tongue image of breast cancer.Methods The breast cancer patients who visited the Department of Hematology and Oncology,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine from June 2019 to January 2021 were selected,and the tongue images of breast cancer patients were collected using the TFDA-1 digital tongue diagnostic apparatus,and Matlab was used for image processing.The system uses the RGB and HSV color model measurement procedures to measure the color parameters of the collected tongue images,and respectively measure:R,G,B,H,S,V.In addition,the purple coefficient P and the yellow coefficient Y are calculated based on R,G,and B.SPSS 20.0 statistical software was used to analyze and compare the tongue color parameters of breast cancer patients with different TCM syndromes,clinical stages and molecular types.Results(1)Objective results of tongue images in breast cancer patientswith different TCM syndromes:(1)Objective parameters of tongue color:Compared with Qi deficiency syndrome and phlegm dampness syndrome,tongue H,tongue B and tongue P of Qi stagnation syndrome and blood stasis syndrome increased;tongue H,tongue R,tongue P and tongue V of heat toxin syndrome increased;tongue H,tongue R,tongue B,tongue P and tongue V of Yin deficiency syndrome increased.Compared with Qi deficiency syndrome,tongue H and tongue P of phlegm dampness syndrome increased.(2)Objective parameters of tongue coating color:Compared with Qi deficiency syndrome,the tongue coating H in the other five groups decreased,the tongue coating R,Y and V in Qi stagnation syndrome,heat toxicity syndrome and blood stasis syndrome increased,and the tongue coating S in phlegm dampness syndrome decreased.Compared with Qi stagnation syndrome,the tongue coating H in phlegm dampness syndrome,blood stasis syndrome and Yin deficiency syndrome increased,the tongue coating Y decreased,and the tongue coating S in phlegm-dampness syndrome decreased.Compared with the heat toxin syndrome,the tongue coating H increased and the tongue coating Y decreased in the phlegm-dampness syndrome,blood stasis syndrome and Yin deficiency syndrome,and the tongue coating R,S and V decreased in the phlegm dampness syndrome.Compared with phlegm dampness syndrome,the tongue coating H and S increased in blood stasis syndrome and Yin deficiency syndrome.(2)Objective results of tongue images in breast cancer patients at different clinical stages:(1)In objective parameters of tongue color,Compared with stageⅡand stageⅣ,the tongue P of breast cancer patients at stage I was increased.(2)In objective parameters of tongue coating color,compared with stageⅣ,the tongue coating R and tongue coating V of breast cancer patients at stage II and stageⅢincreased.(3)Objective results of tongue images in breast cancer patients with different molecular subtypes:(1)There were no significant differences in tongue R,tongue G,tongue B,tongue H,tongue S and tongue V among different Luminal types in objective parameters of tongue color.(2)In objective parameters of tongue coating color,compared with the Her2 positive type and the Triple negative type,tongue coating R and tongue coating V of Luminal A and Luminal B were increased.Conclusions(1)In different syndromes,RGB and HSV color models can reflect the objective characteristics of tongue image in different syndromes of breast cancer to a certain extent.Most of the objective parameters can restore the clinical perspective of TCM syndrome differentiation,and are consistent with TCM theory.fit.(2)In clinical staging,tongue P,coating R,and coating V can reflect the tongue color and coating color of breast cancer in different stages,and to a certain extent can provide an objective reference for the characteristics of tongue image in different stages of breast cancer.(3)In molecular typing,moss R and moss V can reflect the moss color of patients with receptor-positive and receptor-negative breast cancer,and to a certain extent can provide information on the moss color characteristics of receptor-positive and receptor-negative breast cancer patients.