| 纳米材料对大鼠外周血T淋巴细胞亚群的影响 |
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| 引用本文： | 刘焕亮,张华山,杨丹凤,杨红莲,林治卿,闫峻,林本成,田蕾,黄洁华,袭著革. 纳米材料对大鼠外周血T淋巴细胞亚群的影响[J]. 解放军预防医学杂志, 2011, 29(5): 320-324 |
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| 作者姓名： | 刘焕亮 张华山 杨丹凤 杨红莲 林治卿 闫峻 林本成 田蕾 黄洁华 袭著革 |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所,天津,300050 |
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| 基金项目： | 国家高技术研究发展规划(863)项目(No.2006AA032330) |
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| 摘 要： | 目的 探讨纳米银(Nano-Ag)、纳米氧化锌(Nano-ZnO)、纳米二氧化钛(Nano-TiO2)对大鼠的免疫毒性效应.方法 将42只雄性Wistar大鼠随机分为小牛血清对照组,以及3种纳米材料的高剂量组(17.5mg/kg)和低剂量组(3.5mg/kg).非暴露式气管滴注法隔日染毒5周,腹主动脉放血处死,检测大鼠...
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| 关 键 词： | 纳米银 纳米氧化锌 纳米二氧化钛 T淋巴细胞亚群 |
EFFECT OF NANOMATERIALS ON PERIPHERAL BLOOD T LYMPHOCYTES IN RAT |
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| LIU Huan-liang,ZHANG Hua-shan,YANG Dan-feng,YANG Hong-lian,LIN Zhi-qing,YAN Jun,LIN Ben-cheng,TIAN Lei,HUANG Jie-hua,XI Zhu-ge. EFFECT OF NANOMATERIALS ON PERIPHERAL BLOOD T LYMPHOCYTES IN RAT[J]. Journal of Preventive Medicine of Chinese People's Liberation Army, 2011, 29(5): 320-324 |
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| Authors: | LIU Huan-liang ZHANG Hua-shan YANG Dan-feng YANG Hong-lian LIN Zhi-qing YAN Jun LIN Ben-cheng TIAN Lei HUANG Jie-hua XI Zhu-ge |
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| Affiliation: | LIU Huan-liang,ZHANG Hua-shan,YANG Danfeng,YANG Hong-lian,LIN Zhi-qing,YAN Jun,LIN Ben-cheng,TIAN Lei,HUANG Jie-hua,XI Zhu-ge(Institute of Health and Environmental Medicine,Academy of Military Medical Sciences,Tianjin 300050,China) |
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| Abstract: | Objective To investigate the immunotoxicity induced by nanoparticles of silver,zinc oxide,and titanium dioxide in rats.Methods Forty-two Wistar rats were randomly divided into 7 groups,including control group,low and high dose groups of three nanomaterials.The Rats were exposed by intratracheal instillation once every other day for 5 weeks,and then killed by abdominal aorta bloodletting.The changes of peripheral blood T lymphocytes subset,body weight,organ coefficients of spleen,thymus,liver,and kidney in r... |
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| Keywords: | nano-silver nano-zinc oxide nano-titanium dioxide T lymphocyte subset |
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