| 还原型谷胱甘肽治疗全身炎症反应综合征研究 |
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| 引用本文： | 关永东,邓素贞,雷间红,郭永军,陈洁文,江泽慧.还原型谷胱甘肽治疗全身炎症反应综合征研究[J].实用全科医学,2009,7(9):915-916. |
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| 作者姓名： | 关永东 邓素贞 雷间红 郭永军 陈洁文 江泽慧 |
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| 作者单位： | 关永东,邓素贞,雷间红,郭永军,陈洁文(暨南大学第五附属医院急救中心,广东省清远市,511500);江泽慧(暨南大学医学院免疫研究所,511500) |
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| 基金项目： | 广东省卫生厅医学科研基金 |
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| 摘 要： | 目的研究还原型谷胱甘肽（GSH）对治疗全身炎症反应综合征（SIRS）的临床疗效以及对炎性介质的影响，了解GSH对SIRS的治疗价值。方法选择符合SIRS诊断标准的48例患者，随机分为GSH治疗组（A组）和常规治疗组（B组）。观察两组患者的临床效果并检测治疗前后血清IL-6、TNF—Q、C-反应蛋白（CRP）、IL-10水平变化。结果治疗后A组患者临床症状改善较B组明显，MODS发生率下降，炎性介质CRP、IL-6、TNF-α、IL-10水平A组改变较B组明显改善。结论还原型谷胱甘肽能改善SIRS的临床症状，对炎性介质起免疫调理作用。
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| 关 键 词： | 还原型谷胱甘肽 全身炎症反应 炎性介质 |
Clinical Study of the Therapeutic Value of the Reduced Glutathione in Systemic Inflammatory Response Syndrome (SIRS) |
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| Institution: | GUAN Yong-dong, DENG Su-zhen, LEI Jian-hong, et al. (First-aid Centre of Qingyuan People＇s Hospital, Qingyuan 511515, Guangdong, China) |
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| Abstract: | Objective To observe the therapeutic value of the reduced glutathione in critical illness cases with SIRS. Methods 48 SIRS patients were randomly divided into regular treatment group （ group B ） and reduced glutathione treatment group（group A）. The efficacy of the therapy in both the groups were assessed and serum levels of C RP,TNF-α,IL-6 and IL-10 were measured on admission and the fifth day. Results SIRS markers all reduced more significantly in group A than in group B （P〈0.01 ）. Serum CRP, TNF-α and IL-6 levels reduced more significantly in group A than in group B （P 〈 0. 01 ）. Conclusion Reduced glutathione significantly improved the clinical effects of SIRS, prevented the MODS incidence. |
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| Keywords: | Reduced glutathione Systemic inflammatory response syndrome Inflammatory cytokines |
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