Preliminary evidence for the presence of glutathione-s-transferase activity in mammalian and avian brain |
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Authors: | Dixit R Mukhtar H Seth P K Murti C R |
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Affiliation: | Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India. |
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Abstract: | Glutathione-S-transferase activity has been demonstrated in the brain of rabbit, guinea pig, rat, mouse, and pigeon. The activity was in the following order: rabbit > (guinea pig = mouse) > rat > pigeon. The activity of brain was about 1/3 to 1/9 of that present in liver depending upon the species. In the rat brain glutathione-S-transferase activity was found to be distributed equally in cerebrum, cerebellum, and brain stem and localized mainly in the organelle-free cytosol fraction. |
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