| HPLC法测定肾康灵颗粒中丹参素和原儿茶醛的含量 |
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| 引用本文： | 褚克丹,郑健,徐伟,谢伟容,张小琴.HPLC法测定肾康灵颗粒中丹参素和原儿茶醛的含量[J].中国中药杂志,2010,35(13):1699-1701. |
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| 作者姓名： | 褚克丹 郑健 徐伟 谢伟容 张小琴 |
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| 作者单位： | 1. 福建中医药大学药学院,福建,福州,350108
2. 福建中医药大学附属人民医院,福建,福州,350004 |
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| 基金项目： | 福建省自然科学基金课题(2008J0093) |
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| 摘 要： | 目的:建立梯度洗脱测定肾康灵颗粒中丹参素、原儿茶醛含量的HPLC法。方法:Hypersil ODSCl8柱,流动相甲醇-1%冰醋酸溶液,线性梯度洗脱:0～8 min(5∶95),8～11 min(6∶94～5∶95),11～20 min(5∶95);流速1 mL.min-1;检测波长280 nm。结果:在此色谱条件下2种成分可完全分离。丹参素、原儿茶醛的线性范围分别为0.050 4～0.504μg(r=0.999 8),0.109 0～1.090μg(r=0.999 9)。丹参素、原儿茶醛在肾康灵颗粒中的平均回收率分别为98.40%,98.85%,RSD 1.2%,0.87%。结论:该方法简便、准确、快速,可同时测定肾康灵颗粒中丹参素、原儿茶醛的含量。
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| 关 键 词： | 高效液相色谱法 肾康灵颗粒 丹参素 原儿茶醛 含量测定 |
| 收稿时间： | 2010/2/25 0:00:00 |
Determination of tanshinol and protocatechuic aldehydein Shenkangling granula by HPLC |
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| CHU Kedan,ZHENG Jian,XU Wei,XIE Weirong and ZHANG Xiaoqin.Determination of tanshinol and protocatechuic aldehydein Shenkangling granula by HPLC[J].China Journal of Chinese Materia Medica,2010,35(13):1699-1701. |
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| Authors: | CHU Kedan ZHENG Jian XU Wei XIE Weirong and ZHANG Xiaoqin |
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| Institution: | School of pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;People's Hospital of Fujian Province, Fuzhou 350004, China;School of pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;School of pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;School of pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China |
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| Abstract: | |
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| Keywords: | HPLC Shengkangling granula tanshinol protocatechuic aldehyde quantitative analysis |
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