Clinical experience of intrahepatic cholangiocarcinoma associated with hepatolithiasis |
| |
Authors: | Tetsuo Ohta MD Takukazu Nagakawa Ichiro Konishi Keiichi Ueno Masahiro Kanno Takayaoshi Akiyama Masato Kayahara Ryohei Izumi Kohji Konishi Itsuo Miyazaki Makoto Uogishi Hiroshi Sodani |
| |
Institution: | (1) The Department of Gastroenterology, Keiju General Hospital, Nanao, Japan;(2) The Second Department of Surgery, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920 Kanazawa, Japan |
| |
Abstract: | Between 1960 and 1986, seven patients with intrahepatic cholangiocarcinoma and one patient with intrahepatic bile duct adenoma,
related to hepatolithiasis, were seen among 112 cases of hepatolithiasis. Histopathologically, the tumors associated with
hepatolithiasis arose from the periphery of the stone-containing bile duct, spread chiefly along the luminal surface, and
invaded the ductal wall or periductal tissue. The tumors showed papillary to papillo-tubular proliferation and were diagnosed
as the intraductal or periductal spreading type of cholangiocarcinoma. In addition, atypical epithelial hyperplasia was noted
in the vicinity of the tumor area. These findings suggest that chronic relapsing cholangitis in patients with hepatolithiasis
can induce progressive changes to atypical epithelial hyperplasia which may develop into cholangiocarcinoma. |
| |
Keywords: | intrahepatic cholangiocarcinoma hepatolithiasis atypical epithelial hyperplasia of the bile duct |
本文献已被 SpringerLink 等数据库收录! |
|