Serologic and Molecular Characteristics of Hepatitis B Virus among School Children in East Java,Indonesia |
| |
| Authors: | Takako Utsumi Yoshihiko Yano Maria Inge Lusida Mochamad Amin Soetjipto Hak Hotta Yoshitake Hayashi |
| |
| Institution: | Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia; Center for Infectious Diseases, Kobe University Graduate School of Medicine, and Kobe University Graduate School of Health Sciences, Kobe, Japan |
| |
| Abstract: | Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994–1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia. |
| |
| Keywords: | |
|
|
