Association of airway pentosidine levels with bronchodilator response mediated by salbutamol administration in asthmatic patients |
| |
| Authors: | Gakuya Tamagaki Hiroshi Kanazawa Kazuto Hirata |
| |
| Affiliation: | 1. Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100069, China;2. Department of Toxicology, Bayer Pharma AG, 42096 Wuppertal, Germany;3. Department of Pharmacology Vascular Diseases, Cardiology & Hematology, Bayer Pharma AG, 42096 Wuppertal, Germany;4. Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing Hospital, Ministry of Health, Beijing 100730, China;1. Children''s Hospital Srebrnjak, Srebrnjak 100, HR-10000 Zagreb, Croatia;2. Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 10/E, HR-31000 Osijek, Croatia;1. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AB, USA;2. Department of Emergency Medicine, University of Alabama at Birmingham, Birmingham, AB, USA;1. Samodzielna Pracownia Diagnostyki Uk?adu Oddechowego i Bronchoskopii, Uniwersytet Medyczny w Bia?ymstoku, Poland;2. Klinika Pediatrii, Gastroenterologii i Alergologii Dzieci?cej, Uniwersytet Medyczny w Bia?ymstoku, Poland;3. Studium Doktoranckie, Uniwersytet Medyczny w Bia?ymstoku, Poland;4. Klinika Pediatrii, Gastroenterologii i Alergologii Dzieci?cej, Uniwersytecki Dzieci?cy Szpital Kliniczny w Bia?ymstoku, Poland |
| |
| Abstract: | BackgroundRecently, increased levels of pentosidine, an intermolecular cross-linking type of advanced glycation end products, are observed in the airways of asthmatic patients. This study was designed to determine whether differences in bronchodilator response among individuals with asthma are attributable to pentosidine levels in their airways.MethodsFifty-six asthmatic patients (21 with airway obstruction, 35 without airway obstruction) and 10 normal controls were included in this study. For asthmatic patients, we evaluated the spontaneous reversibility of airway obstruction or the reversibility that can be obtained after methacholine provocation. And we also measured pentosidine levels and percentage of sputum eosinophils in induced sputum, and exhaled nitric oxide (NO) levels.ResultsThe pentosidine levels did not significantly differ between the two asthmatic subgroups with and without airway obstruction. In asthmatic patients without airway obstruction, airway hyperresponsiveness to methacholine (PC20 methacholine) was significantly correlated with sputum eosinophils and exhaled NO levels. In contrast, PC20 methacholine was not significantly correlated with pentosidine levels. In asthmatic patients with or without airway obstruction, bronchodilator response was not significantly correlated with sputum eosinophils and exhaled NO levels. However, bronchodilator response was closely correlated with pentosidine levels (asthmatics without airway obstruction: r = ?0.54, p = 0.002; asthmatics with airway obstruction: r = ?0.48, p = 0.03).ConclusionsOur results showed that pentosidine might be a potential biomarker reflecting the reduced bronchodilator response in asthma. This study will provide new insights into the mechanisms underlying persistent airway obstruction. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
