Maternal XX/X chromosome mosaicism in donor oocyte in vitro fertilization (IVF) |
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| Authors: | Paul R Brezina Mindy S Christianson Khanh-Ha D Nguyen Andrew Siegel Andrew T Benner William G Kearns |
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| Institution: | 1. Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, United States;2. Beth Israel Deaconess Medical Center, Harvard Medical School, Cambridge, MA, United States;3. Medical College of Virginia, Richmond, VA, United States;4. Center for Preimplantation Genetics, LabCorp., Rockville, MD 20850, United States |
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| Abstract: | ObjectiveTo evaluate if the degree of maternal X chromosome mosaicism is correlated to the pregnancy loss rate in donor oocyte IVF in women with a Turner syndrome mosaic (TS-Mosaic) diagnosis.DesignProspective trial.Patients and methodsWomen with X chromosome Turner syndrome mosaicism and infertility were enrolled in a clinical trial. The rate of mosaicism was determined through florescence in situ hybridization (FISH) of 500 maternal lymphocytes. Following a detailed medical, including cardiac, evaluation, donor oocyte in vitro fertilization (IFV) was performed and pregnancy and pregnancy loss rates were observed.ResultsThe rates of maternal X chromosome mosaicism noted in the cycles from women with miscarriages (3%, 4%, 4%, and 6%) were not statistically different from cycles in TS-Mosaic women with normal deliveries (3% and 11%). These data suggest that the rate of maternal X chromosome mosaicism does not affect pregnancy loss rates in TS-Mosaic women undergoing donor oocyte IVF. |
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| Keywords: | Turner syndrome Mosaic Mosaicism Pregnancy Donor oocyte IVF |
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