Precision of GE Lunar iDXA for the Measurement of Total and Regional Body Composition in Nonobese Adults |
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| Authors: | Megan P. Rothney Francois-Pierre Martin Yi Xia Maurice Beaumont Cynthia Davis David Ergun Laurent Fay Fiona Ginty Sunil Kochhar Wynn Wacker Serge Rezzi |
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| Affiliation: | 1. Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN, USA;2. College of Education and Human Development, University of Minnesota, Minneapolis, MN, USA;3. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA;1. Universidade de Campinas (Unicamp), Faculdade de Ciências Médicas, Campinas, SP, Brazil;2. Mississippi State University, Department of Kinesiology, Starkville, United States;3. University of Alabama at Birmingham, Department of Physical Therapy, BM, United States;1. Spinal Cord Injury and Disorders Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA;2. Physical Medicine and Rehabilitation Virginia Commonwealth University, Richmond, VA, USA;3. Department of Veterans Affairs Rehabilitation Research & Development Service National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA;4. Departments of Medicine and Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA;5. Kessler Institute for Rehabilitation, West Orange, NJ, USA;6. Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA;1. Department of Radiology, Auckland City Hospital, Auckland, New Zealand;2. Department of Radiology, Hospital Nueve de Octubre, Valencia, Spain;3. Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy;4. Department of Specialized, Diagnostic, and Experimental Medicine, University of Bologna, Sant''Orsola - Malpighi Hospital, Bologna, Italy;5. Radiology Section, Department of Radiological, Oncological and Anatomopathological Sciences, “Sapienza” University of Rome, Rome, Italy;6. Obesity Surgery Center, Department of Emergency-Urgency, General Surgery and Transplantation, University of Bologna, Sant''Orsola - Malpighi Hospital, Bologna, Italy;7. Unit of Metabolic Diseases & Clinical Dietetics, University of Bologna, Sant''Orsola - Malpighi Hospital, Bologna, Italy |
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| Abstract: | Dual-energy X-ray absorptiometry (DXA) is a well-accepted technique for measuring body composition. Knowledge of measurement precision is critical for monitoring of changes in bone mineral content (BMC), and fat and lean masses. The purpose of this study was to characterize in vivo precision of total body and regional body composition parameters using the GE Lunar iDXA (GE Healthcare Lunar, Madison, WI) system in a sample of nonobese subjects. We also evaluated the difference between expert and automatic region-of-interest (ROI) analysis on body composition precision. To this end, 2 total body scans were performed on each subject with repositioning between scans. Total body precision for BMC, fat and lean mass were 0.5%, 1.0%, and 0.5% coefficient of variation (CV), respectively. Regional body composition precision error was less than 2.5% CV for all regions except arms. Precision error was higher for the arms (CV: BMC 1.5%; fat mass 2.8%; lean mass 1.6%), likely owing to the placement of arms relative to torso leading to differences in ROI. There was a significant correlation between auto ROI and expert ROI (r > 0.99). Small, but statistically significant differences were found between auto and manual ROI. Differences were small in total body, leg, trunk, and android and gynoid regions (0.004–2.8%), but larger in arm region (3.0–6.3%). Total body and regional precision for iDXA are small and it is suggested that iDXA may be useful for monitoring changes in body composition during longitudinal trials. |
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