Dynamics of formation of primary and secondary lipid peroxidation products upon copper-dependent oxidation of low-density lipoproteins isolated from blood serum of patients with ischemic heart disease |
| |
| Authors: | O A Azizova T N Vakhrusheva E S Dremina V S Sharov N V Perova I N Ozerova V P Mazaev |
| |
| Institution: | (1) Department of Biophysics, Institute of Physicochemical Medicine, Ministry of Health, Moscow;(2) Department of Biochemistry of Lipids, State Research Center for Preventive Medicine, Ministry of Health, Moscow |
| |
| Abstract: | The kinetics of copper-induced oxidation of lipids in serum low-density lipoproteins from healthy subjects and patients with
ischemic heart disease and documented coronary atherosclerosis is studied. After a 4-h incubation with 40 μM CuSO4, the oxidizability of patients' lipoproteins is higher, judging from the contents of diene conjugates and oxidation products
reacting with thiobarbituric acid. Intergroup differences in the kinetics of the diene conjugate formation are revealed. Statistical
analysis shows that in all studied individuals there is no relationship between the oxidizability of low-density lipoproteins
and the cholesterol content in lipoproteins and serum.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 32–36, July, 1996 |
| |
| Keywords: | lipid peroxidation ischemic heart disease blood |
| 本文献已被 SpringerLink 等数据库收录！ |
|
