半叶马尾藻多糖体内抗肿瘤作用及其机制探讨

In vivo anti-tumor effect of polysaccharide from Sargassum confusum and the mechanisms]

OBJECTIVE: To study the anti-tumor effects of polysaccharide from Sargassum confusum in mice and explore the possible mechanisms. Methods Forty-five mice bearing transplanted tumor S180 were used to study the effects of polysaccharide on the tumor weight, thymus gland and spleen. The changes in serum contents of SOD, glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) content were assayed. RESULTS: The polysaccharide from Sargassum confusum significantly inhibited the growth of S180 tumor in mice and enhanced the functions of the immune organs. SOD content and GSH-PX activity were significantly increased from 350.76+/-31.34 NU/ml, 299.36+/-43.63 U to 487.76+/-16.67 NU/ml,370.90+/-16.49 U(P<0.01), MDA content decreased from 9.46+/-1.77 nmol/ml to 7.26+/-1.18 nmol/ml in the serum after polysaccharide treatment. CONCLUSION: The anti-tumor effect of the polysaccharide from Sargassum confusum can be attributed to improve functions of the immune organs and enhance anti-oxidative capacity in tumor-bearing mice.