Hcy及 VEGF与妊娠高血压疾病的关系

目的：探讨同型半胱氨酸（ Hcy）、血管内皮生长因子（ VEGF）与妊娠高血压疾病（ HDP）的关系及其临床意义。方法选取浙江省瑞安市人民医院2012年1月至2013年12月收治的800例HDP患者为研究对象，其中妊娠高血压375例，轻度子痫305例，重度子痫120例，另选取同期正常孕晚期妇女800例为对照组，分别采用循环酶法及酶类免疫法测定两组血清Hcy、VEGF水平。结果与对照组相比，HDP组孕妇Hcy水平较高，而VEGF水平较低，差异有统计学意义（ t值分别为4．265和5．426，均P＜0．05）。与妊娠高血压组、轻度子痫组相比，重度子痫组孕妇血清Hcy水平较高，差异具有统计学意义（ t值分别为34．575和15．855，均P＜0．05），而VEGF水平较低，差异具有统计学意义（t值分别为9．512和6．906，均P＜0．05）。与预后良好组相比，预后差组孕妇血清Hcy水平较高，VEGF水平较低，差异有统计学意义（t值分别为5．448和6．325，均P＜0．05）。结论Hcy、VEGF水平升高与HDP病情发生、进展及转归具有密切的关系，Hcy、VEGF可作为HDP患者预后的评价指标。

Relationship between plasma Hcy and VEGF levels and HDP

Objective To investigate the clinical significance of homocysteine （Hcy） and vascular endothelial growth factor （VEGF） and their relationship with hypertensive disorders in pregnancy （ HDP）.Methods From January 2012 to December 2013 800 cases of HDP （375 cases of HDP, 305 cases of mild preeclampsia and 120 cases of severe preeclampsia） were admitted in People’s Hospital of Ruian City, and they were selected in HDP group .Another 800 cases of normal pregnant women at third trimester were selected in control group . The serum levels of Hcy and VEGF of two groups were detected with Enzymatic Cycling Assays Method and enzyme immunoassay .Results Hcy level of the HDP group was higher than the control group , but VEGF level was lower .The differences between two groups were significant （t value was 4.265 and 5.426, respectively, both P〈0.05）.Hcy level of the severe preeclampsia group was significantly higher than that of the HDP group and mild preeclampsia group （t value was 34.575 and 15.855, respectively, both P〈0.05）, but VEGF level was significantly lower （t value was 9.512 and 6.906, respectively, both P〈0.05）.Compared with the patients with good prognosis, the patients with poor prognosis had higher Hcy level and lower VEGF level , and the differences were significant （ t value was 5.448 and 6.325, respectively, both P〈0.05）.Conclusion Increased level of Hcy and decreased level of VEGF are closely related with the occurrence , progression and prognosis of HDP .Hcy and VEGF can be considered as evaluating indicators for prognosis of HDP .