| 生地提取物对小鼠不同给药途径的急性毒性研究 |
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| 引用本文： | 夏卉莉,刘力,徐德生,丁礼琴,毛夏萍.生地提取物对小鼠不同给药途径的急性毒性研究[J].时珍国医国药,2010,21(4). |
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| 作者姓名： | 夏卉莉 刘力 徐德生 丁礼琴 毛夏萍 |
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| 作者单位： | 上海中医药大学附属曙光医院,上海,200021 |
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| 摘 要： | 目的 观察生地以低聚糖为主的提取物RGOS的急性毒性. 方法 测定生地RGOS对小鼠灌胃、超声雾化吸入及尾静脉注射3种给药途径的最大给药量或LD_(50),观察给药后的毒性反应及死亡情况,连续14 d. 结果 生地RGOS对小鼠灌胃的最大给药量为49.6 g/kg(119.04 g生药/kg);对小鼠超声雾化吸入的最大给药量为28.8 g/kg(65.38 g生药/kg);对小鼠尾静脉注射的LD_(50)为7.88 g/kg(17.89g生药/kg),其95%平均可信限L_(95)为(7.88±0.61) g/kg.静脉注射后小鼠体质量增长明显低于对照组,于第7天左右基本恢复. 结论 生地RGOS对小鼠灌胃、超声雾化吸入无明显毒性反应;静脉注射有一定的急性毒性,对小鼠体质量增长有一定的抑制作用.
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| 关 键 词： | 生地提取物 急性毒性 最大给药量 |
Study on the Acute Toxicity of Extract of Radix Rehmanniae with Different Routes of Administration in Mice |
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| XIA Hui-li,LIU Li,XU De-sheng,DING Li-qin,MAO Xia-ping.Study on the Acute Toxicity of Extract of Radix Rehmanniae with Different Routes of Administration in Mice[J].Lishizhen Medicine and Materia Medica Research,2010,21(4). |
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| Authors: | XIA Hui-li LIU Li XU De-sheng DING Li-qin MAO Xia-ping |
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| Institution: | XIA Hui-li,LIU Li,XU De-sheng,DING Li-qin,MAO Xia-ping (Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China) |
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| Abstract: | Objective To observe the acute toxicity of the extract of Radix Rehmanniae containing mainly oligosaccharide.Methods The maximum administration dosage and the LD50 of the RGOS were determined intragastrically,ultrasonic atomizing inhalation and intravenous injection in mice.The toxic reaction and the death condition after administrations were observed for consecutive 14 days.Results The maximum administration dosage by intragastrical and ultrasonic atomization inhalation was 49.6 g/kg(119.04 g crude drug /k... |
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| Keywords: | LD_(50) The extraction of Radix Rehmanniae Acute toxicity Maximum administration dosage LD_(50) |
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