| 测定白血病脑脊液中SIL—2R，IL—6表达的临床意义 |
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| 引用本文： | 黎承萍,陈玉,沈阳. 测定白血病脑脊液中SIL—2R，IL—6表达的临床意义[J]. 昆明医学院学报, 2001, 22(3): 55-57 |
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| 作者姓名： | 黎承萍 陈玉 沈阳 |
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| 作者单位： | 1. 昆明医学院第一附属医院血液科
2. 上海第二医科大附属瑞金医院血液科 |
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| 摘 要： | 为了探讨急性淋巴细胞性白血病 (ALL)患者脑脊液中可溶性白介素 - 2受体 (SIL - 2R)、白介素 6(IL - 6)的表达及意义 ,采用双抗夹心ELISA法测定 3 0例ALL患者脑脊液 (CSF)中SIL - 2R ,IL - 6水平 ,并与 10名正常者进行对照 .结果 :ALL合并中枢神经系统白血病 (CNS -L)组较CNS -L已缓解及未合并CNS -L组二者水平显著升高 (P <0 0 1) ;CNS -L已缓解组二者水平接近对照组 (P >0 0 5 ) ;骨髓缓解及好转组二者水平低于治疗无效组 .结果表明 :监测二者水平变化有助于CNS -L早期诊断、估计预后、判断疗效 .
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| 关 键 词： | 急性淋巴细胞性白血病 脑脊液 SIL－2R IL－6 ALL |
| 文章编号： | 1003-4706(2001)03-0055-03 |
| 修稿时间： | 2001-06-10 |
The Clinical Significance of the Determination of Solvable Interleukin-2 Receptor and Interleukin-6 Levels in Cerebral Spinal Fluid of Leukemia Patients |
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| LI Cheng-ping ),CHENG Jue ),SHEN Yang ). The Clinical Significance of the Determination of Solvable Interleukin-2 Receptor and Interleukin-6 Levels in Cerebral Spinal Fluid of Leukemia Patients[J]. Journal of Kunming Medical College, 2001, 22(3): 55-57 |
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| Authors: | LI Cheng-ping ) CHENG Jue ) SHEN Yang ) |
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| Affiliation: | LI Cheng-ping 1),CHENG Jue 2),SHEN Yang 2) |
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| Abstract: | To evaluate the expression of solvable interleukin-2 receptor (sIL-2R) and interleukin-6 (IL-6) in cerebral spinal fluid (CSF) of patients with acute lymphocyte leukemia (ALL), the expressions of sIL-2R and IL-6 were measured by ELISA in CSF of 30 patients with ALL, compared with those from 10 normal controls. The levels of sIL-2R and IL-6 in all patients with central nervous systemic leukemia (CNSL) were significantly higher than those in patients with complete remissioned CNDL and without CNSL (P<0 01). The sIL-2R and IL-6 levels from patients with complete remissioned CNSL were similar to the normal controls (P>0 05). The sIL-2R and IL-6 levels in bone marrow CR or remitted ones were lower than those in failed treatment. In conclusion, the determination of sIL-2R and IL-6 was useful for the early diagnosis, the evaluation of efficacy and the prognosis of CNSL. |
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| Keywords: | Lymphocyte Leukemia Cerebral Spinal Fluid Solvable Interleukin-2 Receptor Interleukin-6 |
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