血清HBsAg定量在乙型肝炎患者临床治疗中的检测意义

目的分析乙型肝炎患者在临床治疗中血清HBsAg含量的变化情况．探讨血清HBsAg含量与HBV—DNA的相关性。方法收集2010年6月至2011年7月间我院感染科的55例乙型肝炎患者，检测抗病毒治疗过程中第1个月、第3个月、第6个月、第9个月和第12个月血清HBsAg、HBV—DNA含量，并对所得数据进行统计学分析。结果乙型肝炎患者经治疗后，血清HBsAg含量显著下降，且在各阶段差异有统计学意义（P〈0．01）。在治疗的前六个月内下降明显并且差异具有统计学意义（P〈0．05），后六个月下降缓慢，差异无统计学意义（P〉0．05）。血清HBsAg含量在HBeAg阳性者与HBeAg阴性者中差异有统计学意义（p〈0．05），治疗前后血清HBsAg含量在HBeAg阳性者中差异有统计学意义（R0．05），在HBeAg阴性者中虽有下降但差异无统计学意义（P〉0．05）：血清HBsAg浓度与HBV—DNA水平存在正相关，其相关系数r=0．425（P〈0．05）。结论乙型肝炎患者经治疗后血清HBsAg含量整体下降；血清HBsAg浓度与HBV—DNA水平呈正相关。

The significance of serum HBsAg quantitative analysis in the clinical treatment of hepatitis B patients

Objective To analyze the change of serum HBsAg in hepatitis B patients after treatment, and to investigate the correlation between serum HBsAg and HBV-DNA. Methods 55 cases of hepatitis B pa- tients in our hospital from June 2010 to July 2011 were collected. HBsAg and HBV-DNA was detected in the 1st, 3th, 6th, 9th and 12th month during antiviral therapy period of time. The datas were analyzed statistically. Results The levels of HBsAg were decreased after treatment and the differences among all stages had statisti- cal significance （P〈 0.01）. The first six months during treatment, serum HBsAg decreased significantly and the difference had statistical significance （P〈 0.05）. The next six months declined slowly and the difference had no statistical significance （P〉 0.05）. There were statistical significance in the difference of serum HBsAg between HBeAg positive patients and HBeAg negative patients （P〈 0.05 ）. The changes of serum HBsAg before and after treatment in HBeAg positive patients had statistical significance （P〈 0.05）, but there were no statistical signifi- cance in the HBeAg negative patients （P〉 0.05）. There was a positive correlation between serum HBsAg and HBV-DNA level. The correlation coefficient r= 0.425 （P〈 0.05）. Conclusion The levels of serum HBsAg are decreased overall after treatment. There is a positive correlation between serum HBsAg and HBV-DNA.