铜绿假单胞菌的临床分布及耐药性分析

目的 分析铜绿假单胞菌（Pseudomonas aeruginosa,PAE）的来源分布及其对常用抗菌药物的耐药情况,指导临床合理用药.方法 收集2010年6月至2011年6月晋中市第一人民医院临床送检标本中分离出的PAE菌株222株.采用微生物BioFosun鉴定分析仪及相关鉴定卡对临床分离病原菌进行细菌鉴定,同时做药物敏感试验,用WHONET 5.5软件进行数据分析.结果 分离的222株PAE主要来源于痰标本,占92.79％,主要分布于呼吸科（31.53％）和神经内科（21.62％）等科室.PAE耐药率最低的是头孢吡肟（14.7％）,其次是美洛培南（16.5％）、哌拉西林/他唑巴坦（17.4％）等,耐药率最高的是氨曲南（69.2％）,其次是左旋氧氟沙星（44.4％）.结论 PAE是医院感染的主要病原菌之一,其耐药性监测对指导临床合理应用抗菌药物,控制医院感染的流行十分重要.

Clinical distribution and drug resistance analysis of Pseudomonas aeruginosa

Objective To investigate the clinical distribution and the antibiotic resistance of Pseu- domonas aerug/nosa（PAE） and to provide the basis for clinical medication. Methods 222 strains PAE isolated in Jinzhong First People＇s Hospital of Shanxi Province from June 2010 to June 2011 were collected and the clinical distribution were analyzed. The isolated bacteria were identified by a microbial BioFosun appraisal an- alyzer and the relevant identification cards, and drug sensitive tests were done at the same time. The test data were analyzed by the WHONET 5.5 software. Results The separated 222 strains of PAE were mainly from sputum, accounting for 92.79%, and mainly distributed in respiratory department（31.53%） and neurological de- partment （21.62%）. Among the antibiotics, the resistance rate to cefepime was the lowest （14.7%）, followed by meropenem（16.5%）, piperaeillin/tazobactam（17.4%）. The resistance rate to aztreonam（69.2%） was highest, fol- lowed by levofloxaein（44.4%）. Conclusion PAE is the major pathogenic bacteria in nosoeomial infection. The surveillance to antimicrobial resistance is very important for guiding the rational application of antibiotics and controlling the prevalence of nosocomial infection.