cTnT早期诊断蒽环类药物心脏毒性的实验研究

目的:研究血清肌钙蛋白T(cT-nT)浓度是否可以成为蒽环类药物心脏毒性早期诊断指标。方法:新西兰雄性兔44只,随机分为对照组(8只)和实验组(36只)。对照组新西兰兔注射等体积的生理盐水;实验组新西兰兔静脉注射多柔比星2 mg/(kg.次),1次/周,根据实验周数不同,实验组分为1周组(8只)、2周组(8只)、4周组(9只)和8周组(11只)。经胸超声心动图测量左室射血分数(LVEF)和左室短轴缩短分数(FS)以及E峰和A峰比值。血清GPBB浓度测量采用ELISA方法。心肌光镜Billingham评分和电镜检查评价多柔比星心脏毒性。结果:8周组新西兰兔LVEF、FS和E/A值均下降,P<0.05。与对照组相比,4周组新西兰兔血清cTnT浓度明显升高,P<0.05;8周组新西兰兔血清cTnT浓度显著高于其他组,P<0.05。光镜下4周组新西兰兔心肌损害比对照组严重,P<0.05;8周组新西兰兔心肌损害最严重,P<0.05。电镜下线粒体水肿和断裂可见于2周组、4周组和8周组,心肌损伤程度与多柔比星累积剂量有关。相关分析提示,血清cTnT浓度与多柔比星累积剂量(r=0.887,P<0.001)及血清cTnT浓度与...

cTnT as a marker for early detection for anthracycline-induced cardiotoxicity

OBJECTIVE: To assess whether serum cTnT level could be a useful marker for the early detection of anthracycline-induced cardiotoxicity.METHODS: Forty-four male rabbits were entered into the study.Eight rabbits were randomly selected to form control group(saline control).The remaining rabbits were randomly selected to create groups 1-4.Group 1 through 4 received intravenous injections of 2 mg/kg doxorubicin at weekly intervals of 1 week(8 rabbits,group 1),2 weeks(8 rabbits,group 2),4 weeks(9 rabbits,group 3)...