| 肝细胞肝癌组织SATB1表达及其临床意义的研究 |
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| 引用本文： | 彭正奎,杨定华,李湘竑,黄毓,张国强,钟克波,毕民平,李光辉. 肝细胞肝癌组织SATB1表达及其临床意义的研究[J]. 中华肿瘤防治杂志, 2011, 18(9): 697-700 |
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| 作者姓名： | 彭正奎 杨定华 李湘竑 黄毓 张国强 钟克波 毕民平 李光辉 |
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| 作者单位： | 1. 南方医科大学南方医院,肝胆外科,广东广州510515
2. 南方医科大学南方医院,检验科,广东广州510515 |
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| 基金项目： | 广东省基金面上项目(C1030281) |
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| 摘 要： | 目的:探讨肝细胞肝癌(HCC)组织中SATB1的表达及其临床意义。方法:用RT-PCR方法和蛋白质印迹法检测40例HCC组织及对应的癌旁组织中SATB1的表达,并分析SATB1蛋白的表达程度与患者临床病理参数、术后复发与转移的关系。结果:HCC组织中SATB1蛋白的表达明显高于癌旁组织,P<0.001。癌组织中SATB1蛋白表达的高低与AFP、肿瘤大小、癌栓、病理分化、TNM分级、术后复发转移有关系,P<0.05;与性别、年龄、乙型肝炎表面抗原、丙型肝炎抗体、肿瘤的数目、肝硬化和包膜无关,P>0.05。结论:SATB1蛋白的表达与HCC的复发转移有关,SATB1有望成为HCC复发与转移的一个新的预后指标。
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| 关 键 词： | 癌,肝细胞 核基质蛋白质类 RT-PCR |
Expression of SATB1 and its clinic significance in hepatocellular carcinoma tissues |
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| PENG Zheng-kui,YANG Ding-hua,LI Xiang-hong,HUANG Yu,ZHANG Guo-qiang,ZHONG Ke-bo,BI Min-ping,LI Guang-hui. Expression of SATB1 and its clinic significance in hepatocellular carcinoma tissues[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(9): 697-700 |
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| Authors: | PENG Zheng-kui YANG Ding-hua LI Xiang-hong HUANG Yu ZHANG Guo-qiang ZHONG Ke-bo BI Min-ping LI Guang-hui |
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| Affiliation: | PENG Zheng-kui,YANG Ding-hua,LI Xiang-hong,HUANG Yu,ZHANG Guo-qiang,ZHONG Ke-bo,BI Min-ping,LI Guang-huiNanfang Hospital,Southern Medical University,Guangzhou 510515,P.R.China |
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| Abstract: | OBJECTIVE: To investigate the correlation of AT-rich sequence-binding protein(SATB1) in hepatocellular carcinoma(HCC) and discuss its clinical significance.METHODS: The expression of SATB1 in 40 cases of HCC tissues and its adjacent tissues was detected by RT-PCR and Western blotting.And the relationships between SATB1 protein expression and the clinical pathological parameters,recurrence and metastasis were analyzed.RESULTS: The expression of SATB1 protein in HCC tissues was higher than that in adjacent ti... |
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| Keywords: | carcinoma hepatocellular nuclear matrix-associated proteins RT-PCR |
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