| MMP-1基因1G/2G多态性与胃癌预后相关性的探讨 |
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| 引用本文： | 宋传贵,刘星,黄昌明,欧周罗,卢辉山,官国先.MMP-1基因1G/2G多态性与胃癌预后相关性的探讨[J].中华肿瘤防治杂志,2011,18(11). |
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| 作者姓名： | 宋传贵 刘星 黄昌明 欧周罗 卢辉山 官国先 |
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| 作者单位： | 1. 福建医科大学附属协和医院肿瘤科,福建福州,350001
2. 复旦大学附属肿瘤医院肿瘤研究所肿瘤科,上海,200032 |
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| 基金项目： | 福建卫生厅青年人才基金(2006-1-29) |
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| 摘 要： | 目的:探讨基质金属蛋白酶-1(MMP-1)基因1G/2G单核苷酸多态性(SNP)与福建地区胃癌人群生存及器官转移之间的可能关系。方法:对102例完整随访的胃癌患者采用外周血基因组DNA,运用PCR-变性高效液相色谱分析(DHPLC)方法进行MMP-1基因1G/2G多态性的基因型鉴定,比较基因型分布差别,以及与胃癌预后及随访过程中器官转移部位的潜在关系。统计学方法采用SPSS软件进行χ2检验、Kaplan-Meier生存分析和Log-rank等计算。结果:胃癌人群中MMP-1基因1G/2G多态性各基因型分布频率分别为1G/1G(15,14.7%),1G/2G(48,47.1%)和2G/2G(39,38.2%);与含1G基因型相比,2G/2G等位基因型携带者的生存率出现非显著性下降趋势,P=0.075;携带2G纯合等位基因型的胃癌患者随访中发生肝脏转移的机会明显加大,P=0.013。结论:MMP-1基因2G/2G基因型可能是影响福建地区胃癌患者生存的不良预后因子之一,携带2G纯合等位基因型可能是发生肝脏转移的危险因素。
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| 关 键 词： | 胃肿瘤 基质金属蛋白酶-1 多态现象(遗传学) 预后 肿瘤转移 |
Impact of 1G/2G polymorphism in MMP-1 gene on survival of gastric cancer |
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| SONG Chuan-gui,LIU Xing,HUANG Chang-ming,OU Zhou-luo,LU Hui-shan,GUAN Guo-xian.Impact of 1G/2G polymorphism in MMP-1 gene on survival of gastric cancer[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(11). |
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| Authors: | SONG Chuan-gui LIU Xing HUANG Chang-ming OU Zhou-luo LU Hui-shan GUAN Guo-xian |
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| Institution: | SONG Chuan-gui1,LIU Xing1,HUANG Chang-ming1,OU Zhou-luo2,LU Hui-shan1,GUAN Guo-xian1 1.Department of Oncology,Affiliated Union Hospital,Fujian Medical University,Fuzhou 350001,P.R.China2.Department of Oncology,Cancer Hospital,Cancer Institute,Fudan University,Shanghai 200032,P.R.China |
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| Abstract: | OBJECTIVE: To explore the potential association between 1G/2G polymorphism in matrix metalloproteinase-1(MMP-1) gene and survival and organ involvement of gastric cancer.METHODS: Totally 102 gastric cancer patients having complete follow-up information up to 5 years were included in the study.Genotype analysis was performed by using polymerase chain reaction(PCR)-based denaturing high performance liquid chromatography(DHPLC).Survival analysis was calculated by Kaplan-Meier model and Log-rank test with SPSS ... |
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| Keywords: | stomach neoplasms matrix metalloproteinase-1 polymorphism genetics prognosis neoplasm metastasis |
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