| 吉西他滨单药治疗32例晚期复发转移性鼻咽癌的临床观察 |
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| 引用本文： | 何樱,熊海林,孙爱华,袁霞.吉西他滨单药治疗32例晚期复发转移性鼻咽癌的临床观察[J].中华肿瘤防治杂志,2011,18(8):620-621,630. |
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| 作者姓名： | 何樱 熊海林 孙爱华 袁霞 |
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| 作者单位： | 惠州市中心人民医院肿瘤内科,广东惠州,516000 |
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| 摘 要： | 为了观察吉西他滨单药治疗晚期鼻咽癌的疗效及不良反应,对32例晚期鼻咽癌患者给予单药吉西他滨治疗。吉西他滨1 000 mg/m2,持续静脉滴入30 min,d1、d8和d15,28 d为1个周期,所有患者完成>2个周期化疗。结果完全缓解2例(6.3%),部分缓解13例(40.6%),稳定9例(28.1%),有效率为46.9%(15/32),疾病控制率为75.0%(24/32)。最常见的不良反应为血液学毒性,Ⅲ～Ⅳ度贫血、白细胞和血小板减少发生率分别为9.4%(3/32)、28.2%(9/32)和15.6%(5/32)。初步研究结果提示,吉西他滨单药治疗晚期鼻咽癌有较好的疗效,毒副反应较轻,患者能耐受。
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| 关 键 词： | 鼻咽肿瘤 药物疗法 治疗效果 |
Treatment of gemcitabine for 32 cases with metastatic and recurrent nasopharyngeal carcinoma |
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| HE Ying,XIONG Hai-lin,SUN Ai-hua,YUAN Xia.Treatment of gemcitabine for 32 cases with metastatic and recurrent nasopharyngeal carcinoma[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(8):620-621,630. |
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| Authors: | HE Ying XIONG Hai-lin SUN Ai-hua YUAN Xia |
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| Institution: | HE Ying,XIONG Hai-lin,SUN Ai-hua,YUAN XiaDepartment of Medical Oncology,Huizhou Municipal Central People's Hospital,Huizhou 516000,P.R.China |
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| Abstract: | The objective of this study was to evaluate the efficacy and toxicities of gemcitabine in the treatment of metastatic nasopharyngeal carcinoma.Thirty two patients received gemcitabine 1 000 mg/m2,d1,d8,d15,continual iv.drip,every 28 days.All the patients administered not less than 2 cycles.Two patients achieved complete response(6.3%) and 13 achieved partial response(40.6%),9 achieved stable disease(28.1%).The overall response rate was 46.9%(15/32).The clinical disease control rate was 75.0%(24/32).The majo... |
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| Keywords: | nasopharyngeal neoplasms drug therapy treatment outcome |
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