|
|||||
|
|
| 乳腺癌患者血清与肿瘤组织VEGF-C表达和淋巴管密度的生物学意义 | |
| 引用本文： | 吴媛,郭俊俊,李恩孝,王国恩.乳腺癌患者血清与肿瘤组织VEGF-C表达和淋巴管密度的生物学意义[J].中华肿瘤防治杂志,2011,18(8). |
| 作者姓名： | 吴媛 郭俊俊 李恩孝 王国恩 |
| 作者单位： | 1. 西安交通大学医学院第二附属医院重症医学科,陕西西安,710004 2. 陕西省肿瘤医院放疗科,陕西西安,710061 3. 西安交通大学医学院第一附属医院肿瘤内科,陕西西安,710061 |
| 摘 要： | 目的:探讨乳腺癌患者术前外周血清中血管内皮生长因子-C(sVEGF-C)水平及术后肿瘤组织中VEGF-C的表达及淋巴管密度(LVD)的水平与肿瘤淋巴转移的关系。方法:ELISA法检测乳腺癌患者术前外周血清VEGF-C水平,免疫组化SP法检测乳腺癌术后肿瘤组织VEGF-C及抗淋巴管内皮透明质酸受体-1(LYVE-1)的表达,并计算对比分析肿瘤组织LVD。结果:乳腺癌患者sVEGF-C值〔(48.30±23.98)ρg/mL〕较乳腺良性病患者〔(6.26±2.37)ρg/mL〕和健康女性〔(4.72±2.09)ρg/mL〕高,组间比较P值均为0.000;sVEGF-C水平与组织VEGF-C表达正相关,VEGF-C阳性表达者sVEGF-C值为(60.75±11.12)ρg/mL,VEGF-C阴性表达者为(29.86±4.47)ρg/mL,差异有统计学意义,P=0.035;sVEGF-C水平、VEGF-C在组织中的表达分别与乳腺癌患者HER-2表达以及腋淋巴结转移相关,P<0.05。VEGF-C、LVD在乳腺癌组织中的表达较乳腺良性病高,LVD与腋淋巴结转移正相关(P=0.018),VEGF-C与LVD正相关,P=0... |
| 关 键 词： | 乳腺肿瘤 血管内皮生长因子-C 淋巴管 淋巴转移 |
Biological significance between levels of VEGF-C in serum and tissue of tumor and lymph vessel density in breast cancer patients |
|
| WU Yuan,GUO Jun-jun,LI En-xiao,WANG Guo-en.Biological significance between levels of VEGF-C in serum and tissue of tumor and lymph vessel density in breast cancer patients[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(8). | |
| Authors: | WU Yuan GUO Jun-jun LI En-xiao WANG Guo-en |
| Institution: | WU Yuan1,GUO Jun-jun2,LI En-xiao3,WANG Guo-en11.Critical Care Medicine Department,Second Affiliated Hospital,Medical College of Xi'an Jiaotong University,Xi'an 710004,P.R.China2.Department of Radiation Oncology,Shanxi Provincial Tumor Hospital,Xi'an 710061,P.R.China3.Department of Oncology,First Affiliated Hospital,P.R.China |
| Abstract: | OBJECTIVE:To study the correlation between tumor lymphatic metastasis and the level of serum vascular endothelial growth factor C(sVEGF-C) in breast cancer patients,the expression of vascular endothelial growth factor C(VEGF-C) in postoperation tumor tissues and the level of lymph vessel density(LVD).METHODS:sVEGF-C level in preoperation breast cancer patients was detected by ELISA.The expression of VEGF-C and LYVE-1 was detected by immunohistochemical technique.LVD level in carcinoma tissues was calculated... |
| Keywords: | breast neoplasms vascular endothelial growth factor C lymphatic vessels lymphatic metastasis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |