| 腺样囊性癌组织神经生长因子及受体表达与神经浸润相关性的探讨 |
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| 引用本文： | 徐东波,孙保存,张利华. 腺样囊性癌组织神经生长因子及受体表达与神经浸润相关性的探讨[J]. 中华肿瘤防治杂志, 2011, 18(14): 1110-1113 |
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| 作者姓名： | 徐东波 孙保存 张利华 |
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| 作者单位： | 1. 天津医科大学病理教研室,天津,300070
2. 天津市肿瘤医院病理科,天津,300061 |
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| 摘 要： | 目的:观察神经生长因子(NGF)及其功能性受体酪氨酸激酶A(TrkA)在腺样囊性癌(ACC)的表达情况,探讨NGF和TrkA在ACC神经浸润(NI)过程中的作用及其意义。方法:47例石蜡包埋ACC标本,常规HE染色,观察有无NI;并依据形态特点将NI类型分为侵入型和围神经型。免疫组织化学检测NGF和TrkA的表达情况。7例新鲜ACC标本,RT-PCR法检测NGF和TrkA的mRNA的表达水平。结果:47例ACC中37例存在NI,其中侵入型25例、围神经型12例。7例新鲜标本5例存在NI。免疫组织化学染色结果显示,NGF在NI组阳性率为86.49%,非NI组为50.00%,侵入型组为92.00%,围神经组为90.00%;TrkA在NI组阳性率为59.46%,非NI组为40.00%,侵入型组为68.00%,围神经组为50.00%。RT-PCR检测结果显示,NGF mRNA的表达水平在NI组较高,TrkA mRNA的表达两组差异无统计学意义。结论:神经周围癌细胞NGF的表达高于远离神经的癌细胞,而其受体TrkA在神经束膜和肿瘤细胞表面均有表达,NGF与其受体的结合促进癌细胞向着神经聚集并沿其生长,形成NI。
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| 关 键 词： | 癌,腺样囊性/病理学 免疫组织化学 神经生长因子类/蛋白质生物合成 |
Expression of nerve growth factor and its receptor on adenoid cystic carcinoma and their correlation with neural invasion |
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| XUDong-bo,SUN Bao-cun,ZHANG Li-hua. Expression of nerve growth factor and its receptor on adenoid cystic carcinoma and their correlation with neural invasion[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(14): 1110-1113 |
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| Authors: | XUDong-bo SUN Bao-cun ZHANG Li-hua |
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| Affiliation: | XU Dong-bo1,SUN Bao-cun1,ZHANG Li-hua21.Department of Pathology,Tianjin Medical University,Tianjin 300070,P.R.China2.Department of Pathology,Tianjin Cancer Hospital,Tianjin 300061,P.R.China |
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| Abstract: | OBJECTIVE: To observe the expression of NGF and its receptor TrkA on ACC,and evaluate the function and relationship between NGF and TrkA in the process of NI on ACC.METHODS: NI was observed by routine HE stain in 47 paraffin-embedded samples,and classify NI into two patterns: infiltrative pattern and circum-neural pattern.The expression of NGF and TrkA was detected by immunohistochemical stain.The mRNA level of NGF and TrkA was analyzed by RT-PCR in 7 fresh ACC samples.RESULTS: NI was found in 37 cases(25 i... |
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| Keywords: | carcinoma adenoid cystic/pathology immunohistochemistry NGF/protein biosgnthesis |
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