| 三阴性乳腺癌组织p53和Ki-67及E-cadherin的表达及其意义 |
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| 引用本文： | 马双慰,周灵飞,鲜渝斌,李向东,何明.三阴性乳腺癌组织p53和Ki-67及E-cadherin的表达及其意义[J].中华肿瘤防治杂志,2011,18(8). |
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| 作者姓名： | 马双慰 周灵飞 鲜渝斌 李向东 何明 |
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| 作者单位： | 重庆市第九人民医院乳腺外科,重庆,400700 |
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| 摘 要： | 目的:探讨p53、Ki-67和E-cad-herin在三阴性乳腺癌(TNBC)组织中的表达及在预后中的意义。方法:42例TNBC患者为TNBC组,随机抽取同期非TNBC42例为对照组,统计2组p53、Ki-67和E-cadherin的表达。结果:p53在TNBC组的表达率为76.19%(32/42),对照组为54.76%(23/42),差异有统计学意义,P=0.039。Ki-67在TNBC组的表达率为85.71%(36/42),对照组为61.90%(26/42),差异有统计学意义,P=0.013。E-cadherin在TNBC组的表达率为45.24%(19/42),对照组为66.67%(28/42),差异有统计学意义,P=0.048。结论:p53、Ki-67的高表达和E-cadherin的低表达与TNBC预后差密切相关。
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| 关 键 词： | 乳腺肿瘤/病理学 乳腺肿瘤/诊断 预后 |
Expressions of p53,Ki-67 and E-cadherin in triple-negative breast cancer and their prognostic significance |
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| MA Shuang-wei,ZHOU Ling-fei,XIAN Yu-bin,LI Xiang-dong,HE Ming.Expressions of p53,Ki-67 and E-cadherin in triple-negative breast cancer and their prognostic significance[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(8). |
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| Authors: | MA Shuang-wei ZHOU Ling-fei XIAN Yu-bin LI Xiang-dong HE Ming |
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| Institution: | MA Shuang-wei,ZHOU Ling-fei,XIAN Yu-bin,LI Xiang-dong,HE MingDepartment of Breast Surgery,Ninth People's Hospital of Chongqing,Chongqing 400700,P.R.China |
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| Abstract: | OBJECTIVE:To investigate the expressions of p53,Ki-67 and E-cadherin in triple-negative breast cancer(TNBC) and their prognostic significance.METHODS:The expressions of p53,Ki-67 and E-cadherin in 42 cases of TNBC were compared with those of 42 cases of non-TNBC by immunohistochemical technology.RESULTS:The expression rate of p53 was 76.19%(32/42) in the TNBC group and 54.76%(23/42) in the control group with a significant difference for their comparison(P=0.039).The expression rate of Ki-67 was 85.71%(36/42... |
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| Keywords: | breast neoplasms/pathology breast neoplasms/diagnosis prognosis |
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