南海软珊瑚Dendronephthya gigantea的化学成分研究

 目的研究南海软珊瑚Dendronephthya gigantea的化学成分。方法采用柱层析法、Sephadex LH-20和反相半制备HPLC等方法分离化合物,根据波谱数据和理化常数确定其结构。结果从南海软珊瑚Dendronephthya gigantea分离得到10个化合物,鉴定为:(4E,8E)-2(hexadecanoylamino)-4,8-octadecadiene-1,3-diol(1),(4E)-2(hexadecanoylamino)-4-octadecane-1, 3-diol(2),乙酰基苯乙胺(3),Cyclo-(Leu-Pro)(4),Cyclo-(Ala-Pro)(5),Cyclo-(Val-Pro)(6),2,4-二氯苯甲酸(7),胸腺嘧啶脱氧核苷(8),胞嘧啶脱氧核苷(9),胆甾醇(10)。结论其中化合物1～9为首次从软珊瑚Dendronephthya gigantea中分离得到。

Study on Chemical Constituents of Soft Coral Dendronephthya gigantea from the South China Sea

OBJECTIVE To study the chemical constituents of Dendronephthya gigantea.METHODS The compounds were isolated and purified by silica gel,Sephadex LH-20,and semi-preparative reverse-phase HPLC.Their structures were identified by their physical and spectral data.RESULTS Ten compounds were isolated from Dendronephthya gigantea and their structures were identified as(4E,8E)-2(hexadecanoylamino)-4,8-octadecadiene-1,3-diol(1),(4E)-2(hexadecanoylamino)-4-octad- ecane-1,3-diol (2),N-phenethylacetamide(3),Cyclo-(Leu-Pro)(4),Cyclo-(Ala-Pro)(5),Cyclo-(Val-Pro)(6),2,4-dichlorobenzoic acid(7),thymidine (8),2'-deoxyuride(9),cholesterol(10).CONCLUSION Compound 1-9 were isolated from Dendronephthya gigantea for the first time.