| 左旋盐酸苯环壬酯鼻腔喷雾剂的局部安全性评价 |
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| 引用本文： | 王晓青,高永良.左旋盐酸苯环壬酯鼻腔喷雾剂的局部安全性评价[J].中国药学杂志,2009,44(10):771-773. |
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| 作者姓名： | 王晓青 高永良 |
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| 作者单位： | 1.解放军总医院第一附属医院 北京 100037;2.军事医学科学院毒物药物研究所 北京 100850 |
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| 摘 要： | 目的对制备的左旋盐酸苯环壬酯鼻腔喷雾剂进行局部安全性评价。方法以蟾蜍上颚黏膜纤毛为模型考察纤毛毒性,以大鼠鼻黏膜形态学检查评价局部刺激性。结果左旋盐酸苯环壬酯鼻喷剂纤毛毒性及对局部刺激性均较小。结论左旋盐酸苯环壬酯鼻喷剂局部用药较安全,具有良好的应用前景。
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| 关 键 词： | 左旋盐酸苯环壬酯 鼻腔喷雾剂 局部刺激性 |
| 收稿时间： | 2009-01-12; |
Safety Assessment of L-Phencynonate Hydrochloride Nasal Spray |
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| WANG Xiao-qing,GAO Yong-liang.Safety Assessment of L-Phencynonate Hydrochloride Nasal Spray[J].Chinese Pharmaceutical Journal,2009,44(10):771-773. |
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| Authors: | WANG Xiao-qing GAO Yong-liang |
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| Institution: | 1.The first affiliated hospital of total hospital of PLA,Beijing 100037,China; 2. Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China |
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| Abstract: | OBJECTIVE To investigate the safety of the L-phencynonate hydrochloride nasal spray for intranasal application. METHODS In situ toad palate mucoas method was used to assess the ciliotoxicity of the spray.Mucous irritation test in rats was carried out by evaluating the structural and specific cellular changes of nasal mucosa after the nasal spray was used for 5 consecutive days,once a day.RESULTS The ciliotoxicity and mucous membrane irritation of L-phencynonate hydrochloride nasal spray were acceptable.CONCLUSION The L-phencynonate hydrochloride nasal spray is safe for intranasal use and has good application prospects. |
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| Keywords: | L-phencynonate hydrochloride" target="_blank">L-phencynonate hydrochloride')" href="#">L-phencynonate hydrochloride nasal spray mucous membrane irritation ciliotoxicity |
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