| 流化床包衣法制备硝苯地平缓释微丸 |
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| 引用本文： | 王立,任君刚.流化床包衣法制备硝苯地平缓释微丸[J].中国药学杂志,2009,44(15):1159-1162. |
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| 作者姓名： | 王立 任君刚 |
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| 摘 要： | 目的 根据液相层积原理，采用流化床包衣法制备了硝苯地平缓释微丸。 方法 采用离心造粒装置制备了硝苯地平速释微丸，将制得的微丸采用微型流化床以 Eudragit? NE30D 包衣制得了 24 h 释药的硝苯地平缓释微丸。 结果 所得缓释微丸体外释放符合一级释放与 Higuchi 方程。 结论 液相层积法制得微丸体外释放符合缓控释制剂的要求。
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| 关 键 词： | 硝苯地平 液相层积法 流化床 缓释微丸 |
| 收稿时间： | 2000-01-01; |
Preparation of Nifedipine Sustained-Release Pellets by Fluid-Bed Coating Technology |
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| WANG Li,REN Jun-gang.Preparation of Nifedipine Sustained-Release Pellets by Fluid-Bed Coating Technology[J].Chinese Pharmaceutical Journal,2009,44(15):1159-1162. |
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| Authors: | WANG Li REN Jun-gang |
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| Institution: | ( 1. <> School of <> <> Pharmacy <> ， <> Harbin <> University <> of Commerce <> ， <> Harbin <> 1 5 00 7 6 ， <> China ; 2.<>School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, <>China |
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| Abstract: | OBJECTIVE Made nifedipine sustained-release pellets by liquid-layering principle and fluid-bed coating technology．METHODS Centrifugal granulation technology was used firstly to prepare nifedipine rapid-release pellets and then sustained-release pellets were prepared with Eudragit? NE30D coating by fluid-bed. RESULTS The release in vitro of prepared nifedipine pellets followed first-order and Higuchi equations. CONCLUSION The pellets prepared by liquid-layering method meet the requirement of sustained preparations. |
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| Keywords: | nifedipine liquid-layering fluid-bed sustained-release pellets |
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