弥漫性脂肪肝的超声定量诊断及其生化指标的相关性分析

目的探讨采用超声定量诊断技术测定肝脏超声声强在弥漫性脂肪肝诊断中的临床价值;分析脂肪肝轻重程度与生化指标值之间的关系。方法 120例（不同程度）弥漫性脂肪肝患者和40例健康对照者纳入研究。根据氢质子磁共振波谱（proton magnetic resonance spectroscopy,1 H-MRS）检查计算的脂肪分数值将患者分为轻、中、重度三组,应用超声定量诊断技术测定右肝及左肝二维图像的感兴趣区（region of interest,ROI）的回声强度（echo intensity,EI）值,收集生化指标天冬氨酸氨基转移酶（aspartatr aminotransferase,AST）、丙氨酸氨基转移酶（alanine aminotransferase,ALT）以及空腹血糖（fasting blood glucose,FBG）值,分析各定量指标与脂肪肝严重程度的关系。结果右肝近场、右肝中场、右肝后场和左肝EI值、ALT、AST值在正常组、轻、中、重度脂肪肝组组间均存在统计学差异（P〈0.05）;脂肪肝分度与右肝近场、右肝中场、右肝和左肝EI值及ALT、AST、FBG均呈显著相关（P〈0.05）。结论采用超声定量诊断技术测定肝脏的EI值能够直接反映脂肪肝病变程度,可为临床分级诊断提供量化的客观信息。

Correlation of Diffuse Fatty Liver Ultrasound and Biochemical Markers of Quantitative Diagnosis

Objective To explore the clinical value of ultrasonic quantitative diagnosis（QLab-ROI）technology to determine the liver ultra sound strong the diagnosis of diffuse fatty liver,and to analyze the relations between the severity of fatty liver disease and biochemical indexes.Method A total of 120 patients with different levels of diffuse fatty liver and 40 healthy controls were included in the study.According to the fat score values by 1 H-MRS the patients were divided into light,medium,and severe groups.The two-dimensional image of the interested area（ROI）of right and left liver was acquired using quantitative ultrasound diagnostic technique to determine the echo intensity（EI）value.Serum biochemical indexes including aspartate aminotransferase（AST）,alanine aminotransferase（ALT）and fasting blood glucose（FBG）were determined.The relationship between quantitative indicators and the severity of fatty liver were analysed.Results EI values in right hepatic near-field and right hepatic midfield,left field and right hepatic liver,and ALT,AST values were significant different among three groups（P〈0.05）Fatty liver indexing and right hepatic near-field and right hepatic midfield,right liver and left hepatic EI values and ALT,AST,FBG were significantly correlated（P〈0.05）.Conclusion Liver EI determination using quantitative ultrasound diagnosis technology can directly reflect the degree of fatty liver disease,and provide quantitative objective information for clinical grading diagnosis.