药店实施哮喘患者药学服务干预的效果评价——Meta分析

目的评价药店实施哮喘患者药学服务干预的效果。方法检索中国期刊网、AcademicSearchPremier(ASP)、Blackwell、Elsevier、JohnWiley等数据库1999年～2006年3月国内、外发表的相关文献,选择以用药咨询、健康教育等为干预措施的随机对照试验,由2位评价者对文献进行筛查。采用ReviewManager4·2软件对符合条件的文献进行Meta分析。结果共有4项试验纳入本研究,哮喘患者样本1298例,异质性分析结果X2=1·28(P=0·73),采用固定效应模型进行统计学分析。与对照组比较,药学服务干预组最大呼气流速改善更明显,合并后的SMD值为0·19,95%的置信区间为0·08～0·30(P=0·0006)。结论开展以用药咨询、健康教育等为主要内容的药学服务可改善哮喘患者的症状,提示在药店开展哮喘药学服务干预项目是一种有效的疾病管理模式。

A Meta-analysis of Effect of Pharmaceutical Care Program in Asthma Patients in Community Pharmacies

OBJECTIVE:To evaluate the meta-analysis effect of pharmaceutical care(PC)program in asthma patients in community pharmacies.METHODS:The author searched 5 electronic databases(China Journal Net,Academic Search Premier(ASP),Blackwell,Elsevier,John Wiley)from 1999 to Mar 2006.And then the randomized controlled trials by the intervention measures of the medicine consultation and health education were made,Moreover,the literatures were selected by 2 valuators.A meta-analysis was conducted by means of Review Manager 4.2 software.RESULTS:We included 4 randomized controlled trials,1 298 asthma patients,homogeneityte test result X2=1.28(P=0.73).Geostatistical analysis is made by fixed effect model.As compared with the control group,the PC program increased patients'PEFRs in PC group significantly(the combined SMD=0.19,95%confidence interval:0.08～0.30(P=0.0 006).CONCLUSION:PC program in community pharmacies is an effective option in asthma prevention and treatment.The pharmaceutical care program in asthma patients in community pharmacies is effective management model of disease.