Heterogeneous malignant non Hodgkin's lymphomas as a causative disorder in lethal midline granuloma |
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Authors: | R Hubert Laeng Heinz A Gerber Thomas Schaffner Kurt H Bürki |
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Institution: | (1) Department of Pathology, University of Bern, Freiburgstrasse 30, CH-3010 Bern, Switzerland |
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Abstract: | Summary The present report describes the results of a combined morphological, enzyme- and immunohistochemical analysis of nine cases of malignant non Hodgkin's lymphomas (NHL) clinically presenting as lethal midline granuloma. In a previous report written before antibodies directed against B and T lymphocytes were available, a histiocytic origin of such neoplasms had been suggested. A panel of antibodies reactive with most B cells (L26, MB1, KiB3) and a majority of T cells (MT1, UCHL1) was applied on paraffin sections of formalin fixed tissues as well as antibodies directed against leukocyte common antigen (LCA), myeloid/histiocyte antigen (MAC 387), lysozyme, alpha-1-antitrypsin, alpha-1-antichymotrypsin, S-100 protein, prekeratin and immunoglobulin light chains. Enzyme histochemistry included tests for non-specific acid esterase, acid phosphatase, betaglucuronidase and chloroacetate esterase. As a result, five T, two B and two unclassified (malignant histiocytosis probable) NHL were identified, indicating distinct heterogeneity of NHL as causative disorders in lethal midline granuloma. |
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Keywords: | Midline granuloma Histochemistry B cell NHL T cell NHL Malignant histiocytosis |
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