原发性肺鳞癌和腺癌MDR1P—糖蛋白的表达及意义

目的：研究原发性肺鳞癌和腺癌ＭＤＲ１Ｐ－糖蛋白（Ｐ－ｇｐ）的表达及其临床意义。方法：应用ＪＳＢ－１Ｐ－ｇｐ单克隆抗体ＬＳＡＢ免疫组化方法，检测１０１例肺癌组织中Ｐｇｐ的表达。结果：１０１例肺癌组织，３１例（３０．７％）Ｐ－ｇｐ阳性表达，腺癌中Ｐ－ｇｐ阳性表达率（４３．８％）显著高于鳞癌（１８．９％）。Ｐ－ｇｐ表达与鳞癌组织学分级有显著关系。高分化组Ｐ－ｇｐ阳性表达率显著高于低分化组；在肺癌，Ｐ－ｇ

DETECTION OF P GLYCOPROTEIN IN SQUAMOUS CARCINOMA AND ADENOCARCINOMA OF THE LUNG

Objective:To study the expression of P glycoprotein(P gp)in squamous carcinoma and adenocarcinoma of lung and to discuss its clinical significance Methods:101 cases of lung cancer was stained with JSB 1 P gp monoclonal antibody by LSAB method Results:Out of 101 lung carcinomas,31(30 7%)were positive in the expression of P gp The positive rate(43 8%)in adenocarcinoma was significantly higher than that (18 9%)in squamous carcinoma Expression of P gp was correlated with histological grade of squamous carcinoma;in adenocarcinoma,P gp expression was correlated with the size of tumor and prognosis of patients Conclusion:Detectable P gp is the cause of drug resistance in lung cancer and P gp expression appears to be an adverse prognostic factor,but there is no obvious correlation between P gp expression and prognosis of squamous carcinoma