| 对乙酰氨基酚体外溶出度测定方法及条件的改进 |
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| 引用本文： | 丁晓萍,熊海疆,李新霞,陈坚. 对乙酰氨基酚体外溶出度测定方法及条件的改进[J]. 新疆医科大学学报, 2003, 26(6): 527-529 |
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| 作者姓名： | 丁晓萍 熊海疆 李新霞 陈坚 |
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| 作者单位： | 1. 新疆医科大学药学院,新疆,乌鲁木齐,830054
2. 新疆富科思生物技术公司,新疆,乌鲁木齐,830022 |
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| 基金项目： | 新疆维吾尔自治区高技术发展计划资助项目(200311110) |
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| 摘 要： | 目的:研究一种实时、在位监测固体制剂体外溶出度的测定方法——光纤化学溶出度过程临测法,考察本法与2000版《中国药典》溶出度测定方法的差异。方法:双分支光纤一端连接光源,公共端部探头浸入溶出液,另一端连接检测器,计算机记录并处理数据。结果:本法监测药物溶出的全过程,同时显示完整的药物溶出曲线图,从原始数据中可直接提取相关参数,与药典方法比较,两种测定方法差异无统汁学意义(P>0.05)。结论:光纤化学溶出度过程监测法能够有效测定固体药物的体外溶出度,并能真实地反映药物溶出的全过程。
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| 关 键 词： | 光纤溶出度过程监测法 溶出度测定方法 对乙酰氨基酚 |
| 文章编号： | 1009-5551(2003)06-0527-03 |
| 修稿时间： | 2003-05-08 |
The improvement of detection method and conditions for dissolution test of paracetamol tablets |
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| DING Xiao-ping,XONG Hai-Jiang,LI Xin-xia,et al. The improvement of detection method and conditions for dissolution test of paracetamol tablets[J]. Journal of Xinjiang Medical University, 2003, 26(6): 527-529 |
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| Authors: | DING Xiao-ping XONG Hai-Jiang LI Xin-xia et al |
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| Affiliation: | DING Xiao-ping,X1ONG Hai-Jiang,LI Xin-xia,et al |
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| Abstract: | Objective: To study a method which can monitor the dissolution rate of drug on-line-Fiber optic chemical sensor dissolution test (FOCSDT). And compare the difference of this method with Ch. P (2000). Methods: Bifurcated optical fiber was used to connect light source and detector and the common end was dipped in the dissolution vessel. The dissolution procession could be monitored through computer. Result: This procession analysis can test the whole process of drug and get dissolution graph . The parameters obtained by FOCSDT had no significant difference compared with the method in Ch. P 2000 ( P >0. 05) . Conclution : This procession analysis can reflect the real dissolution of drug and obtain the total information. |
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| Keywords: | fiber optic chemical sensor dissolution test (FOCSDT) dissolution test paracetamol tablets |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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