Rapid progression of coronary artery disease in the setting of chronic cocaine abuse |
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| Institution: | 1. Physical Medicine and Rehabilitation resident at Mayo Clinic in Rochester, Minnesota, United States;2. Department of Medicine and Biomedical Ethics, Division of General Internal Medicine, Mayo Clinic, Scottsdale, Arizona, United States;3. Biomedical Ethics Research Program, Mayo Clinic, Rochester, Minnesota, United States;4. Center for Ethics, Professionalism, and the Future of Medicine, Accreditation Council for Graduate Medical Education, Chicago, Illinois, United States;1. Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;2. Department of Pediatrics, Section Molecular Genetics, University of Groningen, University Medical Center Groningen, The Netherlands;3. Department of Laboratory Medicine, Center for Liver Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |
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| Abstract: | Two cases of rapidly progressing coronary artery disease in the setting of chronic cocaine abuse are presented. One patient, a 39-year-old female, developed a significant left anterior descending artery (LAD) stenosis over a 10-month period and suffered an acute myocardial infarction (MI). The second patient, a 35-year-old male, developed significant progression of three vessel coronary artery disease (CAD) over 16 months and also suffered an MI temporally related to cocaine use. Though recent cocaine use is typically considered a risk factor for acute cardiac events, chronic use may contribute to the development or rapid progression of coronary artery disease in young patients. |
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