Ethics of predictive DNA-testing for hereditary breast and ovarian cancer |
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| Affiliation: | 1. Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;2. Faculty of Forestry, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;3. BC Ministry of Forests, Lands and Natural Resource Operations & Rural Development, Kamloops, BC V2C 2T3, Canada;4. Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;1. The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China;2. The Department of Information and Engineering, Wenzhou Medical University, Zhejiang, Wenzhou 325000, PR China |
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| Abstract: | The recent identification of gene mutations involved in hereditary cancers increasingly allows for predictive DNA-testing. There is an urgent need to analyse the ethical issues involved. This article concentrates on the ethics of predictive testing for mutations in the breast (and ovarian) cancer genes BRCA1 and -2. Using international guidelines for presymptomatic DNA-testing for Huntington disease and the Li-Fraumeni syndrome as a model, a provisional protocol, which entails four parts is presented: (i) inclusion and exclusion criteria; (ii) preparing for the test; (iii) informing about the results of the test; (iv) post-test counselling and evaluation. The importance of an integral education of both doctors and the public is stressed. |
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