13例血管淋巴样增生伴嗜酸粒细胞增多症的临床和病理分析

目的：探讨血管淋巴样增生伴嗜酸粒细胞增多症（ALHE）的临床表现、病理特点及诊治情况，提高对本病诊断和治疗的认识。方法：分析华山医院1999年1月-2004年12月13例确诊为ALHE患者的临床和病理资料、随访及其转归。结果：本病临床上表现为单发或多发红色至褐色的丘疹或结节，无淋巴结受累，通常局限在头面部和颈部。本病容易被误诊，但特征性的病理改变（包括血管增生、内皮细胞突入管腔以及混合性淋巴细胞、嗜酸粒细胞浸润）有助于确诊。手术切除对单发损害疗效好，而多发损害则治疗困难且客易复发。结论：组织病理学检查对于诊断ALHE是必需的。手术切除的疗效最好，但可以复发。

Clinical and Pathological Analysis of Angiolymphoid Hyperplasia with Eosinophilia in 13 Cases

Objective:To analyze the clinical presentation, pathological feature , therapy and outcome of angiolymphoid hyperplasia with eosinophilia (ALHE). improve the recognition of this rare disease. Methods: We reviewed the clinical findings , pathologic changes and outcome of 13 cases with ALHE from Jan. 1999 to Dec. 2005. Results: Clinically, it was characterized by solitary or multiple, red to brown cutaneous papules or nodules with no lymphadenopathy, usually located on the head and neck. It was easy to be misdiagnozed. However, the characteristics of histological features including a proliferation of blood vessels, distinctive endothelial cells and infiltration with lymphocytes and eosinophils are helpful to establish the diagnosis. Surgical excision was good to solitary lesion while multiple lesions were resistant to conventional therapies and easy to recur. Conclusion: Histopathological examination is necessary for the diagnosis of ALHE. Despite of recurrence, surgical removal of the lesions has demonstrated the best results.